HOXA5、E-cadherin、β-catenin在宫颈癌中的表达及意义  

Expressions and significance of HOXA5,E-cadherin andβ-catenin in cervical cancer

作　　者：田佳[1] 林恒洁 耿通会 杨柳丹 黄艳芳 周英琼[1] TIAN Jia;LIN Hengjie;GENG Tonghui;YANG Liudan;HUANG Yanfang;ZHOU Yingqiong(Affiliated Hospital of Guilin Medical University,Guilin 541001;School of Clinical Medicine,Guilin Medical University,Guilin 541199,China)

机构地区：[1]桂林医学院附属医院,广西桂林541001 [2]桂林医学院临床医学院,广西桂林541199

出　　处：《华夏医学》2023年第4期20-26,共7页Acta Medicinae Sinica

基　　金：国家大学生创新创业训练计划项目(202010601001);广西自然科学基金项目(2018GXNSFAA050049)。

摘　　要：目的:探讨同源异型盒基因A5(HOXA5)、E-钙黏附蛋白(E-cadherin)和β-环连蛋白(β-catenin)的表达与宫颈癌临床病理学特征之间的关系。方法:选取宫颈癌及非癌宫颈的石蜡包埋组织各110例,制成组织芯片,用免疫组织化学法检测HOXA5、E-cadherin和β-catenin的表达,并分析他们之间的关联。结果:①HOXA5、E-cadherin和β-catenin的阳性表达率在宫颈癌组中分别为56.4%、62.7%和72.7%,在非癌宫颈组中分别为87.3%、86.4%和89.1%,3种蛋白在宫颈癌组的表达均低于非癌宫颈组,差异有统计学意义(P<0.05)。②HOXA5和β-catenin的阳性表达与宫颈癌肌层浸润和FIGO分期相关(P<0.05)。③在宫颈癌中,HOXA5与β-catenin的表达呈正相关(r=0.202,P<0.05)。结论:HOXA5、E-cadherin及β-catenin在宫颈癌中表达降低,HOXA5和β-catenin表达与宫颈癌的肌层浸润和FIGO分期相关。Objective:To investigate the relationship between the expression of homologous box gene A5(HOXA5),E-cadherin,β-catenin and the clinicopathological features of cervical squamous cell carcinoma(CSCC).Methods:Paraffin-embedded sections were made from 110 cases of cervical cancer tissues and 110 cases of chronic cervicitis non-cancerous tissues,and then tissue chips were made.The expressions of HOXA5,E-cadherin andβ-catenin in tissue samples were detected by immunohistochemistry and their relationships were analyzed.Results:①The positive expression rates of HOXA5,E-cadherin andβ-catenin in CSCC were 56.4%,62.7%and 72.7%respectively,87.3%,86.4%and 89.1%in normal tissues respectively.The expressions of the three kinds of proteins in CSCC tissues were lower than those in normal tissues,with statistical differences(P<0.05).②The positive expression of HOXA5 andβ-catenin in CSCC were related to the myometrium infiltrated and the stage of FIGO(P<0.05).③The expression of HOXA5 was positively correlated withβ-catenin in cervical cancer(r=0.202,P<0.05).Conclusion:The expression levels of HOXA5,E-cadherin andβ-catenin in CSCC were decreased,and the expressions of HOXA5 andβ-catenin were related to the myometrium infiltration and the stage of FIGO.

关 键 词：同源异型盒基因A5 E-钙黏附蛋白 Β-环连蛋白 宫颈鳞状细胞癌 

分 类 号：R737.33[医药卫生—肿瘤]