PAX7在横纹肌肉瘤和相关软组织肿瘤中的诊断价值分析  

Diagnostic value of PAX7 in rhabdomyosarcoma and related soft tissue tumors

作　　者：赵路 杨娟[2] 刘春梅[2] 吴涵 ZHAO Lu;YANG Juan;LIU Chunmei;WU Han(The Second Affiliated Hospital of Luohe Medical College,Luohe 462000;Luohe Central Hospital,Luohe 462000,China)

机构地区：[1]漯河医学高等专科学校第二附属医院,河南漯河462000 [2]漯河市中心医院,河南漯河462000

出　　处：《华夏医学》2023年第4期27-31,共5页Acta Medicinae Sinica

基　　金：漯河医学高等专科学校2020年度创新创业发展能力提升工程项目(2020-LYZKYZD012)。

摘　　要：目的:探讨PAX7在诊断横纹肌肉瘤和相关软组织肿瘤中的应用价值。方法:选取横纹肌肉瘤患者46例作为研究组,选取同期相关软组织肿瘤患者50例作为参照1组,另收集50例正常组织标本作为参照2组,均行PAX7的免疫组化染色检测。结果:研究组中PAX7基因表达28例,参照1组中PAX7基因表达2例,参照2组中无PAX7基因表达,研究组与参照组之间PAX7基因检出率比较差异均有统计学意义(χ^(2)=61.000,P<0.05);研究组中胚胎性横纹肌肉瘤20例,其PAX7基因分别在胚胎性横纹肌肉瘤、腺泡性横纹肌肉瘤、多形性横纹肌肉瘤、梭形细胞/硬化性横纹肌肉瘤表达各为80.00%、38.46%,71.00%、33.33%。结论:PAX7免疫组化染色对横纹肌肉瘤及相关软组织肿瘤早期鉴别诊断具有一定价值,临床可通过PAX7进行早期分型。Objective:To investigate the application value of PAX7 in the diagnosis of rhabdomyosarcoma and related soft tissue tumors.Methods:46 RMS patients were included in the study group,while another 50 patients with soft tissue tumors in the same period were selected as the control group 1,and 50 normal tissue samples were collected as the control group 2.All groups underwent PAX7 immunohistochemical staining.Results:28 cases of PAX7 gene expression were found in the study group,two cases in control group 1 and none in control group 2.There were statistical differences in the detection rate of PAX7 gene between the study group and the control groups(χ^(2)=61.000,P<0.05).Among the 20 cases of embryonal rhabdomyosarcoma in the study group,PAX7 gene expression in embryonal rhabdomyosarcoma,acinar rhabdomyosarcoma,pleomorphic rhabdomyosarcoma,spindle cell/sclerosing rhabdomyosarcoma was 80.00%,38.46%,71.00%and 33.33%,respectively.Conclusion:PAX7 immunohistochemical staining is valuable for early differential diagnosis of rhabdomyosarcoma and related soft tissue tumors,and can be used for early clinical classification.

关 键 词：横纹肌肉瘤 软组织肿瘤 免疫组化染色 诊断价值 

分 类 号：R730.45[医药卫生—肿瘤]