银花复明汤加减治疗肝经风热型单纯疱疹病毒性角膜炎的价值  

The value of modified Yinhua Fuming decoction in the treatment of herpes simplex virus keratitis of wind-heat type of liver meridian

作　　者：吉鹏 JI Peng(Dept.of Corneal Disease,Nanyang Eye Hospital,Nanyang 473000,China)

机构地区：[1]南阳市眼科医院角膜病科,河南南阳473000

出　　处：《华夏医学》2023年第4期131-135,共5页Acta Medicinae Sinica

摘　　要：目的:探讨银花复明汤加减治疗肝经风热型单纯疱疹病毒性角膜炎(HSK)的价值。方法:选取2021年10月至2022年10月收治的肝经风热型HSK患者103例作为研究对象,随机分为观察组(n=53)和对照组(n=50)。对照组给予更昔洛韦眼用凝胶治疗,观察组在对照组基础上加用银花复明汤加减治疗。比较两组患者临床疗效,视力指数、体征评分、不良反应及复发率。结果:观察组治疗有效率94.3%高于对照组的78.0%,差异有统计学意义(P<0.05)。治疗后,观察组视力指数、体征评分低于对照组(P<0.05);观察组γ-干扰素(IFN-γ)水平高于对照组,C-反应蛋白(CRP)和白细胞介素6(IL-6)水平低于对照组(P<0.05)。观察组复发率3.77%低于对照组的16.0%(P<0.05),两组不良反应差异无统计学意义(P>0.05)。结论:银花复明汤加减治疗肝经风热型HSK可改善眼部症状,抑制炎症,提高治疗效果。Objective:To investigate the value of modified Yinhua Fuming decoction in treating herpes simplex virus keratitis(HSK)of wind-heat type of liver meridian.Methods:103 patients with herpes simplex keratitis of wind-heat type of liver meridian admitted from October 2021 to October 2022 were selected as the study subjects,and were randomized into the observation group(n=53)and the control group(n=50).The control group were given ganciclovir eye gel,while the observation group were treated with modified Yinhua Fuming decoction on the basis of the treatment for the control group.The clinical efficacy,visual index,physical sign score,adverse reactions and recurrence rate were compared between the two groups.Results:The effective rate of treatment in the observation group was 94.3%,higher than 78.0%in the control group,which was of statistical difference(P<0.05).After treatment,the visual indexes and physical sign scores in the observation group were lower than those in the control group(P<0.05);γ-Interferon(IFN-γ)level of the observation group was higher than that of the control group,while levels of C-reactive protein(CRP)and interleukin-6(IL-6)were lower than those of the control group(P<0.05);the recurrence rate in the observation group was 3.77%,lower than 16.0%in the control group(16.0%)(P<0.05),and there was no statistical difference of the incidence of adverse events between the two groups(P>0.05).Conclusion:The modified Yinhua Fuming decoction is effective in treating HSK patients with wind-heat type of liver meridian,which can improve the ocular symptoms and inhibit the inflammatory reactions.

关 键 词：银花复明汤 肝经风热 单纯疱疹病毒 角膜炎 

分 类 号：R772.21[医药卫生—眼科]