纳米酶介导的炎性肠道疾病治疗研究进展  

Reserach Advances on Nanozyme-Guided Therapy of Inflammatory Bowel Diseases

作　　者：陈其文 张先正[1] Chen Qiwen;Zhang Xianzheng(Key Laboratory of Biomedical Polymers of Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072)

机构地区：[1]武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室,武汉430072

出　　处：《化学学报》2023年第8期1043-1051,共9页Acta Chimica Sinica

基　　金：国家重点研发计划(No.2019YFA0905603);国家自然科学基金(Nos.22135005,52131302,51833007);博士后科学基金(Nos.2021TQ0250,2022M712456)资助。

摘　　要：近年来,炎性肠道疾病(Inflammatory bowel diseases,IBD)的发病率越来越高,给全球的公共健康带来了沉重的负担.目前,人们主要使用抗炎药、抗生素、生物抗体及免疫调节剂等药物来抑制炎症反应治疗IBD,但疗效并不理想.生物酶具有高效、专一的催化活性,在炎性疾病诊疗领域引起了广泛的研究兴趣.但生物酶纯化困难、在生物体内易失活,限制了其进一步应用.相比于生物酶,纳米酶制备简单、结构稳定、类酶催化活性高,近年来将纳米酶应用于生物医药领域受到了广泛的关注,如抗癌、抗菌、抗炎等.本综述总结了近年来纳米酶在IBD治疗方面的研究进展,重点介绍了所用纳米酶的组成、合成方法、催化特性及治疗机制.文中进一步讨论了目前用于IBD治疗纳米酶的应用限制,并对未来用于IBD治疗的纳米酶的构建进行了展望.Recently,the increasing morbidity of inflammatory bowel diseases(IBD)has become a threat to public health around the world.At present,anti-inflammatory drugs,antibiotics,biological antibodies,and immunomodulators are widely used to treat IBD through suppressing inflammation response,but the therapeutic effects are not always satisfied.Biological enzymes have highly efficient and specific catalytic activity,which has aroused extensive research interest in diagnosis and treatment of inflammatory diseases.However,bioenzymes are difficult to be purified and are easy to be inactivated within organism,which limits its further applications.Compared with bioenzymes,nanozymes have simple preparation procedure,stable structure and high enzyme-like catalytic activity.Very recently,nanozymes have been widely used in the field of biomedicine,such as anti-cancer,antibacterial,anti-inflammation and so on.In this review,recent research advances of nanozymes for treatment of IBD are summarized by introducing typical studies,focusing on the composition,synthesis methods,catalytic properties and therapeutic mechanisms of the used nanozymes.This review also discusses the limitations of the current application of nanozymes for the treatment of IBD,and the prospect of the future construction of nanozymes for treatment of IBD.

关 键 词：纳米酶 催化活性 抗炎 肠道炎症 

分 类 号：R574[医药卫生—消化系统]