循环肿瘤细胞在结直肠癌诊疗中的应用研究新进展  

Recent progress in the application of circulating tumor cells in the diagnosis and treatment of colorectal cancer

作　　者：王慧[1] 豆小文 周志威 余细球[2] 张秀明 Wang Hui;Dou Xiaowen;Zhou Zhiwei;Yu Xiqiu;Zhang Xiuming(Medical Laboratory of the Third affiliated Hospital of Shenzhen University,Shenzhen 518001,China;Department of Gastroenterology,Shenzhen Luohu People′s Hospital,Shenzhen 518001,China)

机构地区：[1]深圳大学第三附属医院医学检验科,深圳518001 [2]广东省深圳市罗湖区人民医院消化内科,深圳518001

出　　处：《中华检验医学杂志》2023年第9期971-976,共6页Chinese Journal of Laboratory Medicine

基　　金：深圳市医学重点学科(SZXK054);深圳市科技创新基础研究面上项目(JCYJ20190812171215641)。

摘　　要：结直肠癌为常见消化道恶性肿瘤之一,发病率、死亡率位于前列。前移结直肠癌早诊窗口,动态监测术后复发转移风险,提早干预对改善结直肠癌诊疗结局具有重要价值。循环肿瘤细胞(CTC)作为一种快捷无创、可重复取材的液体活检手段之一,已广泛应用于结直肠癌的早期诊断、疗效监测和预后评估,本文系统梳理了CTC计数、蛋白表达(肝再生磷酸酶-3、基质金属蛋白酶-9等)、分子表征(结肠腺瘤样息肉基因、erb-b2受体酪氨酸激酶等)、转运RNA表达谱、单细胞测序在结直肠癌诊疗中的应用研究价值,以期辅助临床合理应用CTC监测指标,为改善结直肠癌的预后提供支撑。Colorectal cancer(CRC),as one of the most common gastrointestinal malignancy,is original from the epithelial/endothelial cells of colorectal tissues.CRC is one of the highest incidence and mortality rates of any malignancy in humans today.Moving forward the early diagnosis window of colorectal cancer,dynamic monitoring of the risk of postoperative recurrence and metastasis,early intervention is of great value in improving the diagnosis and treatment outcome of colorectal cancer.The clinical diagnosis of CRC via circulating tumor cells(CTC)has been considered as one of the fast,noninvasive,reproducible liquid biopsy methods,and it has been widely used in the early diagnosis,treatment monitoring and prognosis evaluation of colorectal cancer.This review systematically expounded the applied research values of CTC counting,protein expression(phosphatase of regenerating liver-3,matrix metalloproteinase,etc),molecular characterization(adenomatous polyp of colon,erb-b2 receptor tyrosine kinase,etc),mRNA expression profile and single cell sequencing in the diagnosis and treatment of colorectal cancer,in order to assist clinical in rational use of CTC monitoring indicators and provide support for improving the prognosis of colorectal cancer.

关 键 词：结直肠肿瘤 诊断 治疗 预后 循环肿瘤细胞 

分 类 号：R735.34[医药卫生—肿瘤]