Newly developed gas-assisted sonodynamic therapy in cancer treatment  

作　　者：Meng Pan Danrong Hu Liping Yuan Yan Yu Yicong Li Zhiyong Qian 

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Collaborative Innovation Center of Biotherapy,Chengdu 610041,China [2]Rehabilitation Medicine Center and Institute of Rehabilitation Medicine,Key Laboratory of Rehabilitation Medicine in Sichuan Province,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第7期2926-2954,共29页药学学报（英文版）

基　　金：funded by the National Natural Science Foundation of China Regional Innovation and Development Joint Fund(Sichuan,NSFCU21A20417);the National Natural Science Foundation of China(NSFC31930067,NSFC32001003);the Natural Science Foundation of Sichuan Province(2022NSFSC1282,China);the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18002,China)。

摘　　要：Sonodynamic therapy(SDT) is an emerging noninvasive treatment modality that utilizes lowfrequency and low-intensity ultrasound(US) to trigger sensitizers to kill tumor cells with reactive oxygen species(ROS).Although SDT has attracted much attention for its properties including high tumor specificity and deep tissue penetration,its anticancer efficacy is still far from satisfactory.As a result,new strategies such as gas-assisted therapy have been proposed to further promote the effectiveness of SDT.In this review,the mechanisms of SDT and gas-assisted SDT are first summarized.Then,the applications of gas-assisted SDT for cancer therapy are introduced and categorized by gas types.Next,therapeutic systems for SDT that can realize real-time imaging are further presented.Finally,the challenges and perspectives of gas-assisted SDT for future clinical applications are discussed.

关 键 词：Sonodynamic therapy Gas therapy Cancer therapy US imaging Sonotheranostics 

分 类 号：R730.5[医药卫生—肿瘤]