An overview of flavonoids from Sophora flavescens(kushen)with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G  

作　　者：Eric Wei Chiang Chan Ying Ki Ng Hung Tuck Chan Siu Kuin Wong 

机构地区：[1]Faculty of Applied Sciences,UCSI University,56000 Cheras,Kuala Lumpur,Malaysia [2]Secretariat of International Society for Mangrove Ecosystems(ISME),Faculty of Agriculture,University of the Ryukyus,Okinawa 903-0129,Japan [3]School of Foundation Studies,Xiamen University Malaysia,Bandar Sunsuria,43900 Sepang,Selangor,Malaysia

出　　处：《Journal of Chinese Pharmaceutical Sciences》2023年第8期603-615,共13页中国药学（英文版）

摘　　要：In this overview,the current knowledge of the constituents of flavonoids isolated from the roots of Sophora flavescens(kushen)is updated.Flavonoids consist of several classes,such as flavanones,flavonols,chalcones,isoflavones,biflavonoids,flavanols,and flavones.The most common compounds are kurarinone(KRN),sophoraflavanone G(SFG),2′-methoxykurarinone,kuraridine,isoxanthohumol,and formononetin.KRN and SFG are two major flavanones with more vital anticancer properties than other flavonoids.From the literature,the cytotoxic values of KRN and SFG are variable and depend on the type of cancer cells tested.The anticancer activities of these two flavonoids involve different molecular mechanisms.Clinical trials are needed before anticancer drugs from KRN and SFG can be developed.

关 键 词：Kushen FLAVANONES CYTOTOXICITY Molecular mechanisms 

分 类 号：R284[医药卫生—中药学]