聚乙烯栓塞微球介入治疗原发性大肝癌的临床效果  

Clinical effects of polyvinyl alcohol embolization microspheres in the interventional treatment of primary large hepatocellular carcinoma

作　　者：车江涛 马小锁 CHE Jiangtao;MA Xiaosuo(Department of Radiology,Jingmen People's Hospital,Jingmen,Hubei Province 448100,China)

机构地区：[1]荆门市人民医院放射科,湖北荆门448100

出　　处：《实用放射学杂志》2023年第8期1338-1341,共4页Journal of Practical Radiology

摘　　要：目的探讨聚乙烯栓塞微球介入栓塞治疗原发性大肝癌的疗效及安全性。方法选取接受经导管动脉化疗栓塞(TACE)治疗的57例原发性大肝癌患者,其中接受聚乙烯栓塞微球加碘化油治疗的35例为实验组,接受单纯碘化油治疗的22例为对照组。比较2组患者的介入栓塞治疗后的肝功能、不良反应等,根据改良实体瘤疗效评价标准(mRECIST)评估治疗疗效,并计算患者总生存期(OS)。结果实验组术后不良反应(腹痛34.3%、发热25.7%)明显低于对照组(腹痛68.2%、发热54.5%),疾病控制率(87.51%)明显高于对照组(59.09%),术后肝功能指标如谷丙转氨酶(ALT)、谷草转氨酶(AST)明显优于对照组(P=0.029,0.001),术后平均生存期[(19.64±2.29)个月]高于对照组[(12.5±1.92)个月](P=0.032)。结论聚乙烯栓塞微球加碘化油的疾病控制率、术后平均生存期及术后肝功能指标优于单纯碘化油,且术后不良反应少。Objective To study the efficacy and safety of polyvinyl alcohol embolization microspheres for interventional embolization in the treatment of primary large hepatocellular carcinoma.Methods The data of 57 patients with primary large hepatocellular carcinoma who underwent transcatheter arterial chemoembolization(TACE)were collected.The patients were divided into two groups,in which 35 cases treated with polyvinyl alcohol embolization microspheres plus lipiodol were divided into the experimental group and 22 cases treated with lipiodol alone were divided into the control group.The liver function and adverse effects after interventional embolization in the two groups were compared,treatment efficacy was accessed according to the modified response evaluation criteria in solid tumors(mRECIST),and the overall survival(OS)of patients was calculated.Results Postoperative adverse reactions in the experimental group(abdominal pain,34.3%;fever,25.7%)were significantly lower than those in the control group(abdominal pain,68.2%;fever,54.5%).The disease control rate(87.51%)was significantly higher than that of the control group(59.09%),while the postoperative liver function indexes such as alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were significantly better than those of the control group(P=0.029,0.001),and the average postoperative survival time was(19.64±2.29)months,higher than that of the control group[(12.5±1.92)months](P=0.032).Conclusion The disease control rate,average postoperative survival and postoperative liver function indexes of the polyvinyl alcohol embolization microspheres plus lipiodol are better than that of the lipiodol,and there are fewer postoperative adverse effects.

关 键 词：肝癌 经导管动脉化疗栓塞 介入治疗 聚乙烯栓塞微球 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]