史蒂文斯-约翰逊综合征继发双侧舌侧缘巨大炎性增生物1例并文献复习  

Stevens-Johnson syndrome secondary to massive inflammatory hyperplasia of bilateral lingual margins:a case report and literature review

作　　者：林鹃 于凡 李晓娜 李冰炎 张瑞璞 谢卫红[1] Lin Juan;Yu Fan;Li Xiaona;Li Bingyan;Zhang Ruipu;Xie Weihong(Dept.of Oral and Maxillofacial Surgery Ward 2,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院口腔颌面外二科,郑州450000

出　　处：《华西口腔医学杂志》2023年第5期599-603,共5页West China Journal of Stomatology

摘　　要：史蒂文斯-约翰逊综合征(SJS)又称重症多形红斑型药疹,为一类主要由药物过敏所引起的皮肤和黏膜的不良反应,常累及口腔、眼及外生殖器黏膜,常伴发热,严重者可危及生命。郑州大学第一附属医院口腔科于2022年2月收治1名SJS继发双侧舌缘巨大炎性增生物的患者,入院时除舌增生物无其他明显症状。患者曾于2月前因服用对乙酰氨基酚产生严重药物不良反应致SJS,合并肝功异常及肺部感染,治疗康复1月后继发舌部增生物,遂收入郑州大学第一附属医院口腔颌面外二科,完善检查后手术切除舌部增生物,随访11个月,患者情况可,无不适。SJS继发舌增生物的病例极其罕见,口腔科医师如遇类似病例,应详细询问药物过敏史及近期用药史,警惕其是否近期发生过药物不良反应。Stevens-Johnson syndrome(SJS),also known as the multifactorial erythematous drug eruption,is a class of adverse reactions of the skin and mucous membranes primarily caused by drug allergy often involving the oral cavity,eyes,and external genital mucosa,generally accompanied by fever,and can be life-threatening in severe cases.In February 2022,the Department of Stomatology,the First Affiliated Hospital of Zhengzhou University admitted a patient with huge inflammatory hyperplasia of bilateral lingual margins secondary to SJS.Upon admission,no other obvious symptoms were observed except for tongue hyperplasia.The patient suffered from a severe adverse drug reaction caused by acetaminophen 2 months ago and was complicated by liver dysfunction and pulmonary infection.After 1 month of treatment and rehabilitation,he developed a secondary tongue mass and was subsequently admitted to Dept.of Oral and Maxillofacial Surgery Ward 2,the First Affiliated Hospital of Zhengzhou University.After completing the examination,the tongue mass was surgically removed.After a follow-up of 11 months,the patient’s condition was satisfactory and no temporary discomfort was observed.The case of tongue mass secondary to SJS is extremely rare.If a stomatologist encounters a similar case,we should carefully inquire about the drug allergy history and recent medication history,and be alert to whether or not they had adverse drug reactions recently.

关 键 词：史蒂文斯-约翰逊综合征 药物不良反应 口腔黏膜 

分 类 号：R781.67[医药卫生—口腔医学]