Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality?  

作　　者：Juan Du Xuelai Liu Carol Wing Yan Wong Kenneth Kak Yuen Wong Zhixin Yuan 

机构地区：[1]Diabetic Foot Diagnosis and Treatment Centre,Jilin Province People Hospital,Changchun,Jilin,China [2]Department of Surgery,Capital Institute of Pediatrics Affiliated Children Hospital,Beijing,China [3]Department of Surgery,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong SAR,China [4]Department of Emergency Surgery,Jilin Province People Hospital,Changchun,Jilin,China

出　　处：《Chronic Diseases and Translational Medicine》2023年第3期191-199,共9页慢性疾病与转化医学（英文版）

基　　金：The Creation and Innovation Project of Jilin Province,Grant/Award Number:2022C043‐11;Shenzhen Healthcare Research Project,Grant/Award Number:201505018;The Science and Technology Project of Jilin Province,Grant/Award Number:20210203079SF;The Health Technology Promotion Project of Jilin Province,Grant/Award Number:2022JC001。

摘　　要：Induced pluripotent stem cell(iPSC)technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years.Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs.Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments.This indicates the potential“stem”characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour.In this review,we described the morphology and biological function of fibroblasts.The stem cell characteristics and activities of fibroblasts,including transdifferentiation into myofibroblasts,osteogenic cells,chondrogenic cells,neurons,and vascular tissue,are discussed.The biological values of fibroblasts are then briefly reviewed.Finally,we discussed the potential applications of fibroblasts in clinical practice.

关 键 词：direct cellular reprogramming FIBROBLAST wound healing 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]