2012-2022年中国幽门螺杆菌流行病学Meta分析  

Meta-analysis of epidemiology of Helicobacter pylori infection in China from 2012 to 2022

作　　者：朱红梅 刘颖初 薛元 汪红兵[1] ZHU Hongmei;LIU Yingchu;XUE Yuan;WANG Hongbing(Department of Gastroenterology,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京中医医院消化中心,北京100010 [2]北京中医药大学,北京100029

出　　处：《预防医学情报杂志》2023年第9期1124-1137,共14页Journal of Preventive Medicine Information

摘　　要：目的 综合评价中国幽门螺杆菌的感染现状,以期提供高级别的流行病学证据,为后续研究提供参考。方法 检索中国知网、万方、维普、中国生物医学文献数据库、Pubmed、Web of Science于2012-2022年发表的有关幽门螺杆菌流行病学的文献,采用R.4.2.1软件进行Meta分析,使用随机效应模型汇总合并,最终得到其合并感染率及95%置信区间。结果 共纳入68篇文献,总样本量为258 631例,其中107 127例幽门螺杆菌阳性。Meta分析结果显示,2012-2022年中国幽门螺杆菌感染率为42.11%[95%CI(38.86%,45.37%)];亚组分析结果显示:从地理区域来看,西北地区感染率最高,为45.71%[95%CI(37.80%,53.62%)],东北地区感染率最低,为26.00%[95%CI(15.69%,36.30%)];从检测方法来看,用尿素呼气实验检测的幽门螺杆菌感染率最高,为45.36%[95%CI(41.81%,48.92%)],用粪便抗原方法检测的幽门螺杆菌感染率最低,为30.10%[95%CI(6.04%,54.16%)];2012-2016年报告的感染率为45.27%[95%CI(40.56%,49.88%)],2017-2022年报告的感染率为39.14%[95%CI(34.17%,43.57%)]。结论 2012-2022年中国幽门螺杆菌感染率约为42.11%,相比之前54.76%已有所下降,不同地理区域及检测方法的幽门螺杆菌感染率不同。Objective To comprehensively evaluate the prevalence of Helicobacter pylori infection in China,to provide high-level epidemiological evidence,so that to provide reference for the follow-up research.Methods The studies on the H.pylori infection were searched,which was published by China National Knowledge Infrastructure,Wanfang Data,VIP,Sinomed,Pubmed and Web of Science from 2012 to 2022.Meta-analysis s was conducted by R.4.2.1 software.A random effects model was operated to calculate pooled prevalence,the co-infection rate with 95%CIs were finally obtained.Results A total of 68 articles with 258631 subjects were included,of which 107127 were infected with H.pylori.The results of meta-analysis showed that the pooled H.pylori prevalence in China was 42.11%[95%CI(38.86%,45.37%)]J.Subgroup anlaysis results showed that:in terms of geographical area,the rate of H.pylori in northwest China was the highest,at 45.71%[95%CI(37.80%,53.62%)],while the Northeast region had the lowest rate at 26.00%[95%CI(15.69%,36.30%)].In terms of detection methods,the H.pylori infection detected by urea breath test was the highest,at 45.36%[95%CI(41.81%,48.92%)],and the lowest prevalence of infection detected by stool antigen test was 30.10%[95%CI(6.04%,54.16%)].The prevalence was 45.27%[95%CI(40.56%,49.88%)]in the period 2012-2016,the prevalence was 39.14%[95%CI(34.17%,43.57%)]in the period 2017-2022.Conclusions From 20122 to 2022,the infection rate of H.pylori in China was 42.11%,which has decreased compared with 54.76%,and the rate of H.pylori is different in various geographical regions and detection methods.

关 键 词：幽门螺杆菌 流行病学 META分析 中国 

分 类 号：R57[医药卫生—消化系统] R181.3[医药卫生—内科学]