天冬化学成分和药理作用的研究进展及其质量标志物的预测分析  

Research Progress on Chemical Components and Pharmacological Effects of Asparagi Radix and Predictive Analysis of Its Quality Marker

作　　者：张渝渝[1] 魏江平 谭春斌[1] 周兴[1] 祝卢艺[1] 赵领 朱可欣 周莹莹 瞿显友[1] 刘丹 阳勇[1] 张小梅[1] Zhang Yuyu;Wei Jiangping;Tan Chunbin;Zhou Xing;Zhu Luyi;Zhao Ling;Zhu Kexin;Zhou Yingying;Qu Xianyou;Liu Dan;Yang Yong;Zhang Xiaomei(Materia Medica State Administration of Traditional Chinese Medicine Third Level Lab.of Chemistry/Luzhou Key Lab.of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing,Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China;Luzhou Key Lab.of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,China;School of Pharmacy,Zunyi Medical University,Zunyi 563000,China;Neijiang Academy of Agricultural Sciences of Sichuan Province,Neijiang 641000,China)

机构地区：[1]重庆市中药研究院国家中医药管理局中药化学三级实验室/川渝共建慢病中药新药泸州市重点实验室,重庆400065 [2]西南医科大学附属中医医院川渝共建慢病中药新药泸州市重点实验室,四川泸州646000 [3]遵义医科大学药学院,贵州遵义563000 [4]四川省内江市农业科学院,四川内江641000

出　　处：《中国野生植物资源》2023年第9期70-80,共11页Chinese Wild Plant Resources

基　　金：国家重点研发计划(2021YFD1601005);四川省科技厅四川省区域创新合作项目(23QYCX0043);四川省区域创新合作项目(2023YFQ0007);四川省科技计划项目(2022YFN0032);内江天冬种苗工厂化繁育及生态种植技术研究项目。

摘　　要：天冬为《中华人民共和国药典》收载的传统大宗中药材,为滋阴清热的常用药,具有延缓衰老、降压降糖、抗肿瘤、抗菌、抗炎、增强免疫以及保护神经等作用,是一种颇具发展前景的中药材。本研究对天冬的化学成分和药理作用进行综述,并基于质量标志物(Q-marker)的理念,从化学成分、成分有效性、在不同药物配伍中的表达成分及成分可测性等方面对天冬质量标志物成分进行预测分析,为控制天冬的质量和完善其质量标准提供参考。Asparagi Radix is a traditional bulk Chinese medicinal herb included in the Pharmacopoeia of the People's Republic of China.It is a commonly used medicine for nourishing yin and clearing heat,and has functions such as delaying aging,lowering blood pressure and blood sugar,anti-tumor,antibacteri‐al,anti-inflammatory,enhancing immunity,and protecting nerves.It is a promising Chinese medicinal herb.This study provides a review of the chemical compositions and pharmacological effects of Asparagi Radix,and based on the concept of quality markers(Q-markers),predicts and analyzes the components of Asparagi Radix from the perspectives of chemical composition,component effectiveness,expression of components in different drug combinations,and component measurability.This provides a reference for controlling the quality of Asparagi Radix and improving its quality standards.

关 键 词：天冬 化学成分 药理作用 质量标志物 

分 类 号：R284[医药卫生—中药学]