细胞外囊泡与口腔肿瘤免疫  

Extracellular vesicles and oral tumor immunity

作　　者：肖博林 张伟[1,2] 陈刚[1,2,3] XIAO Bolin;ZHANG Wei;CHEN Gang(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China)

机构地区：[1]口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院,湖北武汉430079 [2]武汉大学泰康生命医学中心,湖北武汉430071 [3]武汉大学免疫与代谢前沿科学中心,湖北武汉430071

出　　处：《口腔医学》2023年第9期769-774,共6页Stomatology

基　　金：国家自然科学基金专项项目(82341023)。

摘　　要：细胞外囊泡是由细胞分泌的纳米级膜性小泡,是细胞间通信的重要载体。肿瘤细胞所分泌的细胞外囊泡不仅影响肿瘤的发生和发展,还可通过与免疫细胞的交互作用介导肿瘤免疫逃逸和治疗抵抗。基于细胞外囊泡的液体活检以及靶向细胞外囊泡的治疗策略在肿瘤治疗中具有较好的应用前景。该文阐述了细胞外囊泡的生物学特性及其在口腔肿瘤免疫调控和逃逸中的作用和机制,并探讨了基于细胞外囊泡的口腔肿瘤诊疗新策略,为推动细胞外囊泡的临床转化应用提供了理论依据。Extracellular vesicles are nanoscale membranous vesicles secreted by cells and are an important mediator for intercellular communication.Tumor-derived extracellular vesicles not only affect tumorigenesis and progression,but also mediate tumor immune escape and therapeutic resistance through interaction with immune cells.Liquid biopsies based on extracellular vesicles and therapeutic strategies targeting extracellular vesicles have promising applications in tumor therapy.This paper describes the biological properties of extracellular vesicles and their role in immune regulation of oral tumors,and discusses therapeutic strategies for oral tumors based on extracellular vesicles,providing a theoretical basis for promoting the clinical translation of extracellular vesicles.

关 键 词：细胞外囊泡 口腔肿瘤 免疫细胞 生物标志物 免疫治疗 

分 类 号：R739.8[医药卫生—肿瘤]