病毒感染相关天疱疮  

Viral infection-related pemphigus

作　　者：周航帆 江潞()[1] ZHOU Hangfan;JIANG Lu(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Oral Medicine,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院口腔黏膜病科,四川成都610041

出　　处：《口腔医学》2023年第9期854-860,共7页Stomatology

基　　金：国家自然科学基金(82171809);中国医学科学院临床与转化医学研究专项项目(2022-I2M-C&T-B-111)。

摘　　要：天疱疮是一组可累及全身皮肤黏膜的自身免疫性大疱性疾病,其病因主要包括遗传易感性及环境因素两大类。病毒感染作为重要的环境因素被认为与天疱疮的发生关系密切。单纯疱疹病毒、肝炎病毒及其他类型的病毒感染均可能是天疱疮的触发因素;其潜在机制涉及分子拟态、抗原抗体免疫复合物的持续形成及异常的T细胞亚群分化及功能等多方面;对于合并病毒感染的天疱疮患者,常规糖皮质激素或免疫抑制剂治疗联合抗病毒治疗往往能取得更好的疗效。该文从病毒感染与天疱疮的关系、潜在致病机制以及临床治疗方案选择方面对病毒感染相关天疱疮作一综述。Pemphigus is a group of autoimmune bullous diseases that can affect skin and mucosa.The etiology mainly includes genetic susceptibility and environmental factors.As one of the critical environmental factors,virus infection is considered to be closely related to the occurrence of pemphigus.Herpes simplex virus,hepatitis virus,and other viral infections may all trigger pemphigus.The potential mechanism involves molecular mimicry,continuous formation of antigen-antibody immune complexes,and abnormal differentiation and function of T cell subsets.Pemphigus patients with viral infection may benefit from combining conventional glucocorticoid or immunosuppressive therapy and antiviral therapy.This article reviews the relationship between viral infection and pemphigus,the potential pathogenic mechanism,and the selection of clinical treatment options for viral infection-related pemphigus.

关 键 词：天疱疮 寻常型天疱疮 病毒感染 自身免疫 抗病毒治疗 

分 类 号：R781.53[医药卫生—口腔医学]