虚拟现实-图像视觉诱发电位用于客观评定单眼屈光不正视觉损伤的价值  

The Value of VR-PVEP in Objective Evaluation of Monocular Refractive Visual Impairment

作　　者：郝虹霞 陈捷敏 王荣荣 俞晓英 王萌 周智露 盛延良[1] 夏文涛 HAO Hong-xia;CHEN Jie-min;WANG Rong-rong;YU Xiao-ying;WANG Meng;ZHOU Zhi-lu;SHENG Yan-liang;XIA Wen-tao(Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases,School of Basic Medicine,Jiamusi University,Jiamusi 154007,Heilongjiang Province,China;Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Ministry of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;Shanghai NCC Electronic Co.,Ltd.,Shanghai 200245,China;School of Forensic Medicine,Guizhou Medical University,Guiyang 550009,China)

机构地区：[1]佳木斯大学基础医学院微生态-免疫调节网络与相关疾病重点实验室,黑龙江佳木斯154007 [2]司法鉴定科学研究院上海市法医学重点实验室司法部司法鉴定重点实验室上海市司法鉴定专业技术服务平台,上海200063 [3]上海诺诚电气股份有限公司,上海200245 [4]贵州医科大学法医学院,贵州贵阳550009

出　　处：《法医学杂志》2023年第4期382-387,共6页Journal of Forensic Medicine

基　　金：国家重点研发计划资助项目(2022YFC3302001);上海市科技成果转化和产业化项目(19441914500);中央级科研院所基本科研业务费资助项目(GY2018G-2);司法部司法鉴定重点实验室资助项目;上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目。

摘　　要：目的研究单眼不同程度视觉损伤情况下,双眼同时刺激与单眼刺激时虚拟现实-图像视觉诱发电位(virtual reality-pattern visual evoked potential,VR-PVEP)P100波形的特点。方法选取视力正常(采用小数记录法,远视力≥0.8且近视力≥0.5)的青年志愿者55名,使用插片法模拟单眼屈光不正视觉损伤,分别使单眼近视力与远视力之和≤0.2(A组,即重度视觉损伤)、0.2<近视力与远视力之和<0.8(B组,即中度视觉损伤)、近视力与远视力之和≥0.8(C组,即轻度视觉损伤)。同时,将双眼正常视力设为对照组。在16×16、24×24、32×32、64×644种空间频率下对单眼和双眼同时刺激所测得的VR-PVEPP100峰时进行比较。结果A组中视觉损伤眼与双眼同时视测得的P100峰时在24×24、32×32和64×64空间频率下的差异均有统计学意义(P<0.05),视觉损伤眼与健眼测得的P100峰时在64×64空间频率下的差异具有统计学意义(P<0.05)。B组中视觉损伤眼与双眼同时视测得的P100峰时在16×16、24×24和64×64空间频率下的差异均有统计学意义(P<0.05),视觉损伤眼与健眼测得的P100峰时在64×64空间频率下的差异具有统计学意义(P<0.05)。C组中视觉损伤眼与双眼同时视测得的P100峰时在全空间频率下的差异均无统计学意义(P>0.05)。对照组的单眼视与双眼同时视测得的P100峰时在全空间频率下的差异均无统计学意义(P>0.05)。结论VR-PVEP可用于对单眼中、重度视觉损伤者进行视力评估,能够反映屈光不正导致的视觉损伤眼的视力损伤程度,在视觉功能客观评定及法医临床鉴定中具有应用价值。Objective To study the virtual reality-pattern visual evoked potential(VR-PVEP)P100 waveform characteristics of monocular visual impairment with different impaired degrees under simultaneous binocular perception and monocular stimulations.Methods A total of 55 young volunteers with normal vision(using decimal recording method,far vision≥0.8 and near vision≥0.5)were selected to simulate three groups of monocular refractive visual impairment by interpolation method.The sum of near and far vision≤0.2 was Group A,the severe visual impairment group;the sum of near and far vision<0.8 was Group B,the moderate visual impairment group;and the sum of near and far vision≥0.8 was Group C,the mild visual impairment group.The volunteers’binocular normal visions were set as the control group.The VR-PVEP P100 peak times measured by simultaneous binocular perception and monocular stimulation were compared at four spatial frequencies 16×16,24×24,32×32 and 64×64.Results In Group A,the differences between P100 peak times of simulant visual impairment eyes and simultaneous binocular perception at 24×24,32×32 and 64×64 spatial frequencies were statistically significant(P<0.05);and the P100 peak time of normal vision eyes at 64×64 spatial frequency was significantly different from the simulant visual impairment eyes(P<0.05).In Group B,the differences between P100 peak times of simulant visual impairment eyes and simultaneous binocular perception at 16×16,24×24 and 64×64 spatial frequencies were statistically significant(P<0.05);and the P100 peak time of normal vision eyes at 64×64 spatial frequency was significantly different from the simulant visual impairment eyes(P<0.05).In Group C,there was no significant difference between P100 peak times of simulant visual impairment eyes and simultaneous binocular perception at all spatial frequencies(P>0.05).There was no significant difference in the P100 peak times measured at all spatial frequencies between simulant visual impairment eyes and simultaneous binocular perce

关 键 词：法医学 创伤和损伤 视觉 屈光不正 视力障碍 虚拟现实-图像视觉诱发电位 

分 类 号：R89[医药卫生—法医学] DF795.1[医药卫生—临床医学] D919.1[政治法律—诉讼法学]