摄食抑制因子-1与腹腔镜结直肠癌根治术后肝转移的关系分析  

Analysis of the relationship between ingestion inhibition factor-1 and liver metastasis after laparoscopic radical resection of colorectal cancer

作　　者：常剑 邱峰 毛郁琪 Chang Jian;Qiu Feng;Mao Yuqi(Suzhou Jiulong Hospital,School of Medicine,Shanghai Jiaotong University,Suzhou Jiangsu Province 215000,China)

机构地区：[1]上海交通大学医学院苏州九龙医院,江苏苏州215000

出　　处：《中华普外科手术学杂志（电子版）》2023年第5期502-505,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：江苏省卫生健康委员会项目(LGY2022017)。

摘　　要：目的:分析摄食抑制因子-1(Nesfatin-1)与腹腔镜结直肠癌根治术后肝转移的关系。方法:纳入2019年1月至2021年12月期间行腹腔镜结直肠癌根治术的83例患者进行前瞻性队列研究,所有患者均在入院时测定血清Nesfatin-1水平并依据其中位值119.8 pg/ml将患者分为高水平组(n=37)与低水平组(n=46),所有患者自出院之日起采用门诊复诊方式跟踪随访1年,统计两组患者随访期间肝转移发生情况,采用SPSS 25.0处理数据,计量资料以(^(-)x±s)表示,组间比较行独立样本t检验;计数资料采用频数或率表示,采用χ2检验;等级资料采用秩和检验,相关性分析采用点二列相关进行检验;采用多因素Logistics回归分析检验,绘制受试者工作特征曲线(ROC),以曲线下面积(AUC)检验Nesfatin-1水平对结直肠癌根治术患者发生肝转移的预测价值。P<0.05为差异有统计学意义。结果:高水平组神经累及占比高于低水平组(P<0.05);高水平组Nesfatin-1水平(124.3±12.9)pg/ml及肝转移发生占比均高于低水平组(116.2±13.0)pg/ml(24.3%vs.6.5%),差异有统计学意义(P<0.05);Nesfatin-1水平与腹腔镜结直肠癌根治术患者肝转移发生呈正相关(r=0.331,P<0.05);多因素Logistics回归分析校正后神经累及混杂因素后,Nesfatin-1仍是腹腔镜结直肠癌根治术患者肝转移发生的独立危险因素(OR=1.119,95%CI:1.036-1.209,P=0.004);受试者工作特征曲线(ROC)显示,Nesfatin-1对腹腔镜结直肠癌根治术后肝转移发生情况的预测效能较好。结论:Nesfatin-1与腹腔镜结直肠癌根治术后肝转移发生情况独立相关,其对腹腔镜结直肠癌根治术后肝转移的预测效能较好,或可作为腹腔镜结直肠癌患者根治术后肝转移的预测指标。Objective To analyze the relationship between dietary inhibitory factor 1(Nesfatin-1)and liver metastasis after laparoscopic radical resection of colorectal cancer.Methods A prospective cohort study of 83 patients who underwent laparoscopic radical resection for colorectal cancer between January 2019 and December 2021 was included.Serum Nesfatin-1 levels were measured in all patients upon admission,and patients were divided into a high level group(n=37)and a low level group(n=46)according to a median value of 119.8pg/ml.All patients were followed up for 1 year from the date of discharge by outpatient revisit.The incidence of liver metastasis in the two groups during the follow-up period was analyzed using SPSS 25.0 data.The measurement data were expressed as(^(-)x±s),and inter-group independent sample t test was performed.The counting data were expressed by frequency or rate andχ2 test was used.Rank sum test was used for rank data,and point two-column correlation was used for correlation analysis.The receiver operating characteristic curve(ROC)was drawn using multi-factor Logistics regression analysis,and the area under the curve(AUC)was used to test the predictive value of Nesfatin-1 level in liver metastasis in patients undergoing radical resection of colorectal cancer.P<0.05 was considered statistically significant.Results The proportion of nerve involvement in high level group was higher than that in low level group(P<0.05).The level of Nesfatin-1(124.3±12.9)pg/ml and the incidence of liver metastases in the high level group were higher than those in the low level group(116.2±13.0)pg/ml and the incidence of liver metastases(24.3%),the difference was statistically significant(P<0.05).Nesfatin-1 level was positively correlated with liver metastasis in patients undergoing laparoscopic radical resection for colorectal cancer(r=0.331,P<0.05).After adjusting for nerve involvement and confounding factors,Nesfatin-1 was still an independent risk factor for liver metastasis in patients undergoing laparoscopic radi

关 键 词：结直肠肿瘤 直肠结肠切除术 腹腔镜 摄食抑制因子-1 肝转移 

分 类 号：R735.37[医药卫生—肿瘤]