斩断肿瘤细胞的营养来源——低碳水化合物生酮饮食对肿瘤细胞代谢的影响  

Cutting off the source of nutrients for tumor cells-the Cutting off the source of nutrients for tumor cells——the effect of low-carbohydrate ketogenic diet on tumor cell metabolismeffect of low-carbohydrate ketogenic diet on tumor cell metabolism

作　　者：马逸飞 杨乃龙[1] Ma Yifei;Yang Nailong(Department of Endocrine,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong,China)

机构地区：[1]青岛大学附属医院内分泌科,山东青岛266003

出　　处：《肿瘤代谢与营养电子杂志》2023年第4期462-466,共5页Electronic Journal of Metabolism and Nutrition of Cancer

摘　　要：近年来,随着对肿瘤细胞的营养方式与代谢路径研究的逐渐深入,饮食在肿瘤进展中的影响受到了广泛关注。目前普遍认为,与正常细胞相比,多数肿瘤细胞高度依赖以葡萄糖为底物的有氧糖酵解过程产能,而缺乏利用酮体的能力,于是通过限制碳水化合物摄入、提升血酮体浓度切断肿瘤细胞的营养来源,进而遏制肿瘤细胞生长及分裂的论点应运而生。本文将简明地阐述肿瘤细胞的营养代谢机制,从多个角度探讨低碳水化合物生酮饮食方案对肿瘤细胞产生和代谢的影响。In recent years, the influence of daily diet on tumor progression has received extensive attention with the research on the nutrition method and metabolic pathway in tumor cells much deeper. It is generally recognized that, compared with normal cells, most tumor cells are highly dependent on the aerobic glycolysis based on glucose to obtain energy, whereas unable to utilize amino acids and ketone bodies. Therefore, it is proposed to cut off the nutrient source of tumor cells through restricting carbohydrate intake, thus restraining tumor cells from growing and divising. This review aims to describe the nutritional and metabolic mechanism of tumor cells concisely, and discuss about the effects low-carbohydrate ketogenic diet has on the apparence and metabolism of tumor cells from various perspectives.

关 键 词：肿瘤 肿瘤细胞 生酮饮食 低碳水化合物饮食 肿瘤细胞代谢 临床意义 

分 类 号：R730[医药卫生—肿瘤]