Bifurcations for counterintuitive post-inhibitory rebound spike related to absence epilepsy and Parkinson disease  

作　　者：王宪军 古华光 贾雁兵 陆博 周辉 Xian-Jun Wang;Hua-Guang Gu;Yan-Bing Jia;Bo Lu;Hui Zhou(School of Mathematics and Science,Henan Institute of Science and Technology,Xinxiang 453003,China;School of Aerospace Engineering and Applied Mechanics,Tongji University,Shanghai 200092,China;School of Mathematics and Statistics,Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]School of Mathematics and Science,Henan Institute of Science and Technology,Xinxiang 453003,China [2]School of Aerospace Engineering and Applied Mechanics,Tongji University,Shanghai 200092,China [3]School of Mathematics and Statistics,Henan University of Science and Technology,Luoyang 471000,China

出　　处：《Chinese Physics B》2023年第9期206-219,共14页中国物理B（英文版）

基　　金：the National Natural Science Foundation of China(Grant Nos.12072236,11872276,and11802086);the Postdoctoral Research Project of Henan Province,China(Grant No.19030095);the Science and Technology Development Program of Henan Province,China(Grant No.212102210543)。

摘　　要：Seizures are caused by increased neuronal firing activity resulting from reduced inhibitory effect and enhancement of inhibitory modulation to suppress this activity is used as a therapeutic tool.However,recent experiments have shown a counterintuitive phenomenon that inhibitory modulation does not suppress but elicit post-inhibitory rebound(PIR)spike along with seizure to challenge the therapeutic tool.The nonlinear mechanism to avoid the PIR spike can present theoretical guidance to seizure treatment.This paper focuses on identifying credible bifurcations that underlie PIR spike by modulating multiple parameters in multiple theoretical models.The study identifies a codimension-2 bifurcation called saddle-node homoclinic orbit(SNHOB),which is an intersection between saddle node bifurcation on invariant cycle(SNIC)and other two bifurcations.PIR spike cannot be evoked for the SNIC far from the SNHOBbut induced for the SNIC close to the SNHOB,which extends the bifurcation condition for PIR spike from the well-known Hopf to SNIC.Especially,in a thalamic neuron model,increases of conductance of T-type Ca^(2+)(TC a)channel induce SNIC bifurcation approaching to the SNHOB to elicit PIR spikes,closely matching experimental results of the absence seizure or Parkinson diseases.Such results imply that,when inhibition is employed to relieve absence seizure and Parkinson diseases related to PIR spike,modulating SNIC to get far from the SNHOBto avoid PIR spike is the principle.The study also addresses the complex roles of TCacurrent and comprehensive relationships between PIR spike and nonlinear conceptions such as bifurcation types and shapes of threshold curve.

关 键 词：bifurcation threshold post-inhibitory rebound spike brain disease 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学] TN911.7[电子电信—通信与信息系统]