Protective effects of tanshinoneⅡA on sepsis-induced multiple organ dysfunction:a literature review  

作　　者：WANG Lili FENG Ju ZHAN Daqian WANG Junshuai ZHOU Daixing 

机构地区：[1]Emergency Department and Intensive Care Unit,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Journal of Traditional Chinese Medicine》2023年第5期1040-1046,共7页中医杂志（英文版）

基　　金：Natural Science Foundation of Hubei Province:Mechanism of Degenerative Aortic Valve Calcification Induced by Inflammatory Responses in Valvular Interstitial Cells(No.2020CFB577)。

摘　　要：TanshinoneⅡA(TanⅡA)is a noteworthy lipophilic diterpene compound derived from the dried roots of the Traditional Chinese Medicine Danshen(Radix Salviae Miltiorrhizae)that has various pharmacological properties,including anti-inflammatory,antibacterial,and antioxidative effects.Sepsis is a life-threatening organ dysfunction induced by a dysregulated host response to infection.Recently,increasing attention has been paid to sepsis-induced dysfunction of the intestine,cardiovascular system,lungs,kidneys,liver,and other organs.Experimental studies have shown that TanⅡA has therapeutic potential for sepsis-induced organ dysfunction owing to its anti-inflammatory,anti-apoptotic and regulatory effects on multiple signalling pathways.The purpose of this article is to evaluate the potential multiorgan protective effects of TanⅡA in sepsis.

关 键 词：tanshinoneⅡA SEPSIS multiple organ failure REVIEW 

分 类 号：R285[医药卫生—中药学]