围绝经期综合征细胞模型的建立及评价方法研究进展  

Research progress in establishment and evaluation of cell models for perimenopausal syndrome

作　　者：康梦娇 张伟[1,2] 赵林华 KANG Mengjiao;ZHANG Wei;ZHAO Linhua(Gansu University of Chinese Medicine,Lanzhou 730000,China.;Institute of Metabolic Diseases,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053)

机构地区：[1]甘肃中医药大学,兰州730000 [2]中国中医科学院广安门医院代谢病研究所,北京100053

出　　处：《中国比较医学杂志》2023年第8期139-146,共8页Chinese Journal of Comparative Medicine

基　　金：中国中医科学院科技创新工程项目(CI2021A01605);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-D-202001)。

摘　　要：围绝经期综合征(perimenopauseal syndrome,PMS)是由雌激素和孕酮等类固醇激素水平下降引起的一系列以自主神经系统功能紊乱,伴有神经心理症状的一组症候群,严重影响女性的身心健康和生活质量。体外构建细胞模型是研究PMS的有效方法之一。通过分析研究该疾病的细胞模型,为疾病的治疗提供方向。本文通过检索PubMed、EMbase、Web of science数据库中近年来涉及细胞模型应用于PMS的相关文献,通过总结并系统分析PMS细胞模型建立方法、评价指标及模型特点,对该细胞模型应用于PMS的研究进展进行了综述,以期对PMS细胞模型合理构建及深入研究提供借鉴与思路。Perimenopausal syndrome is a series of autonomic nervous system dysfunctions caused by decreased levels of steroid hormones such as estrogen and progesterone,which is accompanied by neuropsychological symptoms of a group of syndromes NS seriously affecting women’s physical and mental health as well as quality of life.Establishing a cell model in vitro is an effective method to study PMS.Analyzing and studying a cell model of this disease may provide treatment guidance.In this review,the related literature involving the application of cell models of PMS in recent years in PubMed,Embase and Web of Science databases were searched,and the establishment method,evaluation indicators,and model characteristics of cell models for PMS are summarized and systematically analyzed.The research progress of cell models of PMS was reviewed to provide a reference and ideas for the reasonable establishment and in-depth study of cell models for PMS.

关 键 词：围绝经期综合征 细胞模型 评价方法 模型特点 研究进展 

分 类 号：R-33[医药卫生]