肝纤维化的发病机理及相关信号转导机制研究进展  

Research progress on the pathogenesis and related signal transduction mechanisms of liver fibrosis

作　　者：李明芳 李曹飞 左东泽 赵营莉 余士贝 谢耀辉 彭家志[1] 刘建军[1] LI Mingfang;LI Caofei;ZUO Dongze;ZHAO Yingli;YU Shibei;XIE Yaohui;PENG Jiazhi;LIU Jianjun(Department of Pharmacy,the Second People’s Hospital of Hefei(Hefei Hospital of Anhui Medical University),Hefei 230011,China.;Department of General Surgery,People’s Hospital of Fengyang County,Chuzhou 233100)

机构地区：[1]合肥市第二人民医院(安徽医科大学附属合肥医院)药学部,合肥230011 [2]凤阳县人民医院,普外科,安徽滁州233100

出　　处：《中国比较医学杂志》2023年第8期147-152,共6页Chinese Journal of Comparative Medicine

基　　金：安徽医科大学校科研基金(2019xkj087);蚌埠医学院校科研基金(BYKY2019304ZD)。

摘　　要：肝硬化是由各种原因导致的肝细胞外基质过度增生与分解的失衡所致的疾病,是多种肝疾病向肝硬化发展的关键环节。肝纤维化的发生过程是可逆的,主要是肝损伤导致肝星状细胞活化后形成肌纤维细胞,过度沉积在肝内,进而发生肝纤维化,其后果常导致不可逆的肝硬化甚至肝癌的发生。目前对于肝纤维化的具体发病机理及相关分子信号转导机制尚不明确。因此,深入探索肝纤维化的发病机制对抗肝纤维化靶点药物研究具有重要意义,为此,本文主要基于国内外相关文献,结合近年来有关肝纤维化的发病机理及相关信号转导研究作一综述。Cirrhosis is caused by an imbalance of hyperplasia and extracellular matrix decomposition in the liver for various reasons,and it is a major link between various liver diseases to the development of cirrhosis.The process of liver fibrosis is reversible.Liver injury leads to activation of hepatic stellate cells to form muscle fibrocytes,excessive extracellular matrix deposition in the liver,and then liver fibrosis.Its consequences often lead to irreversible cirrhosis and even liver cancer.The specific pathogenesis and molecular signal transduction mechanism of liver fibrosis are unclear.Therefore,it is important to explore the pathogenesis of hepatic fibrosis and investigate anti-fibrotic target drugs.To this end,this article reviews the pathogenesis of liver fibrosis and the related signal transduction studies.

关 键 词：肝纤维化 病理机制 肝星状细胞 信号转导 

分 类 号：R-33[医药卫生]