代谢型谷氨酸受体5正电子发射断层扫描成像在神经精神性疾病中应用的研究进展  

Research progress in the application of metabolic glutamate receptor 5 positron emission tomography in neuropsychiatric diseases

作　　者：张林悦 黄琪 华逢春 ZHANG Linyue;HUANG Qi;HUA Fengchun(Department of Nuclear Medicine,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;PET Center,Huashan Hospital Affiliated to Fudan University,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院核医学科,上海200032 [2]复旦大学附属华山医院PET中心,上海200032

出　　处：《中国医药导报》2023年第26期47-50,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(82201583)。

摘　　要：代谢型谷氨酸受体5(mGluR5)在神经精神性疾病中发挥重要作用,正电子发射断层成像(PET)可无创性在活体分子水平评估神经系统疾病的mGluR5变化。为进一步探明mGluR5在神经精神类疾病中的变化及病理机制,本文就mGluR5的分子机制及其PET在阿尔茨海默病、帕金森病、癫痫、精神性疾病、睡眠与觉醒等的应用中作一综述,以期为mGluR5显像的实验研究及临床应用提供指导意义。Metabolic glutamate receptors 5(mGluR5)play an important role in neuropsychiatric diseases,positron emission tomography(PET)can noninvitatively assess mGluR5 changes in nervous system diseases at the in vivo molecular level.In order to further explore the changes and pathological mechanism of mGluR5 in neuropsychiatric diseases,this paper reviews the molecular mechanism of mGluR5 and the application of PET in Alzheimer’s disease,Parkinson disease,epilepsy,mental diseases,and sleep and arousal,etc.,in order to provide guidance for the experimental research and clinical application of mGluR5 imaging.

关 键 词：代谢型谷氨酸受体5 正电子发射断层显像 阿尔茨海默病 帕金森病 癫痫 精神性疾病 睡眠与觉醒 

分 类 号：R743.3[医药卫生—神经病学与精神病学]