解郁清心汤联合超低频经颅磁刺激对肝郁血虚型帕金森病伴抑郁的治疗效果  

Therapeutic effect of Jieyu Qingxin Decoction combined with ultra-low frequency transcranial magnetic stimulation on Parkinson disease with depression of liver stasis and blood deficiency type

作　　者：项尚 周涛 王业群 洪亮 方无杰 XIANG Shang;ZHOU Tao;WANG Yequn;HONG Liang;FANG Wujie(Department of Neurology,Traditional Chinese Hospital of Lu’an,Anhui Province,Lu’an 237000,China)

机构地区：[1]安徽省六安市中医院神经内科,安徽六安237000

出　　处：《中国医药导报》2023年第26期100-103,109,共5页China Medical Herald

基　　金：安徽省中医药传承创新科研项目(2020ccyb14)。

摘　　要：目的探讨解郁清心汤联合超低频经颅磁刺激对肝郁血虚型帕金森病伴抑郁的治疗效果。方法选取2020年6月至2022年4月安徽省六安市中医院收治的135例肝郁血虚型帕金森病伴抑郁患者为研究对象,采用随机数字表法分为对照组1、对照组2、观察组,各45例。对照组1采用常规治疗+超低频经颅磁刺激治疗,对照组2采用常规治疗+解郁清心汤治疗,观察组采用常规治疗+解郁清心汤+超低频经颅刺激治疗,4周为1个疗程,治疗3个疗程。比较三组临床疗效;比较三组治疗前后帕金森综合评分量表(UPDRS)评分、蒙哥马利抑郁评定量表(MADRS)评分、中医证候积分;观察治疗期间不良反应发生情况。结果观察组临床疗效优于对照组1、对照组2(P<0.05)。治疗后,三组UPDRS、MADRS评分、中医证候积分低于治疗前,且观察组低于对照组1、对照组2(P<0.05)。三组均未发生严重不良反应。结论解郁清心汤联合超低频经颅磁刺激治疗能够有效改善肝郁血虚型帕金森病伴抑郁患者症状,且安全性良好。Objective To explore the therapeutic effect of Jieyu Qingxin Decoction combined with ultra-low frequency transcranial magnetic stimulation on Parkinson disease with depression of liver stasis and blood deficiency type.Methods A total of 135 patients with Parkinson disease with depression of liver stasis and blood deficiency type admitted to Lu’an Traditional Chinese Hospital of Lu’an in Anhui Province from June 2020 to April 2022 were selected as subjects,and they were divided into control group 1,control group 2,and observation group by random number table method,with 45 cases in each group.The control group 1 was treated with conventional treatment+ultra-low frequency transcranial magnetic stimulation,the control group 2 was treated with conventional treatment+Jieyu Qingxin Decoction treatment,and the observation group was treated with conventional treatment+Jieyu Qingxin Decoction+ultra-low frequency transcranial magnetic stimulation treatment,four weeks for one course,treatment of three courses.The clinical efficacy was compared;and the scores of the unified Parkinson disease rating scale(UPDRS),Montgomery-Asberg depression rating scale(MADRS),the traditional Chinese medical syndrome score before and after treatment were compared;the occurrence of adverse reactions during the treatment were observed.Results The clinical efficacy of observation group was better than that of control group 1 and control group 2(P<0.05).After treatment,the scores of UPDRS,MADRS,and traditional Chinese medical syndrome score of three groups were lower than those before treatment,and observation group was lower than that of control group 1 and control group 2(P<0.05).No serious adverse reactions occurred in three groups.Conclusion Jieyu Qingxin Decoction combined with ultra-low frequency transcranial magnetic stimulation can effectively improve the symptoms of patients with Parkinson disease with depression of liver stasis and blood deficiency type,and has good safety.

关 键 词：帕金森病伴抑郁 肝郁血虚 超低频经颅磁刺激 解郁清心汤 

分 类 号：R742.5[医药卫生—神经病学与精神病学]