密封蛋白-4和血管上皮钙黏素在前列腺癌中的表达及相关性  

Expression and correlation of claudin-4 and vascular E-cadherin in prostate cancer

作　　者：孔慧梅 张春霆[2] 郑志彬 KONG Huimei;ZHANG Chunting;ZHENG Zhibin(Medical College,Jinhua Polytechnic,Zhejiang Province,Jinhua 321017,China;Department of Urology,Jinhua People’s Hospital,Zhejiang Province,Jinhua 321000,China;Department of Traditional Chinese Medicine,Jin Pan Development Zone Hospital,Zhejiang Province,Jinhua 321000,China)

机构地区：[1]金华职业技术学院医学院,浙江金华321017 [2]浙江省金华市人民医院泌尿外科,浙江金华321000 [3]浙江省金华市金磐开发区医院中医科,浙江金华321000

出　　处：《中国医药导报》2023年第26期122-125,共4页China Medical Herald

基　　金：浙江省金华市科技局社会发展公益类项目(2020-4-097);浙江省基础公益研究计划项目(LGF20H050002);浙江省金华市科学技术研究计划重大项目(2021-3-027)。

摘　　要：目的探讨密封蛋白-4和血管上皮钙黏素在前列腺癌中的表达及相关性。方法选取浙江省金华市人民医院泌尿外科2015年1月至2017年12月收治的82例前列腺癌患者的癌及癌旁组织作为研究对象,采用免疫组织化学染色对其进行密封蛋白-4和血管上皮钙黏素的检测。比较不同特征前列腺癌患者癌组织密封蛋白-4和血管上皮钙黏素阳性率的差异,分析密封蛋白-4和血管上皮钙黏素表达的相关性。结果前列腺癌患者癌组织密封蛋白-4、血管上皮钙黏素阳性表达率均高于癌旁组织,差异有统计学意义(P<0.05)。不同Gleason评分、TNM分期、术前前列腺特异性抗原(PSA)及精囊浸润的前列腺癌患者密封蛋白-4阳性表达率比较,差异有统计学意义(P<0.05)。不同Gleason评分、TNM分期、术前PSA、精囊浸润及切缘状况前列腺癌患者血管上皮钙黏素阳性表达率比较,差异有统计学意义(P<0.05)。相关性分析结果显示,前列腺癌患者密封蛋白-4和血管上皮钙黏素呈正相关(r>0,P<0.05)。结论前列腺癌患者中,密封蛋白-4和血管上皮钙黏素表达增高,其异常表达值得临床关注。Objective To investigate the expression and correlation of claudin-4 and vascular E-cadherin in prostate cancer.Methods The cancer and adjacent tissues of 82 patients with prostate cancer admitted to the Department of Urology,Jinhua People’s Hospital in Zhejiang Province from January 2015 to December 2017 were selected as the study objects,and the claudin-4 and vascular E-cadherin were detected by immunohistochemical staining.The positive rates of claudin-4 and vascular E-cadherin in cancer tissues of prostate cancer patients with different characteristics were compared,and correlation between claudin-4 and vascular E-cadherin expression was analyzed.Results The positive expression rates of claudin-4 and vascular E-cadherin in prostate cancer tissues were higher than those in adjacent tissues,and the differences were statistically significant(P<0.05).The positive expression rate of claudin-4 in prostate cancer patients with different Gleason score,TNM stage,preoperative prostate-specific antigen(PSA),and seminal vesicle infiltrating were significantly different(P<0.05).The positive expression rate of vascular E-cadherin in prostate cancer patients with different Gleason score,TNM stage,preoperative PSA,seminal vesicle infiltration,and resection margin were significantly different(P<0.05).Correlation analysis showed that there was a positive correlation between claudin-4 and vascular E-cadherin in prostate cancer patients(r>0,P<0.05).Conclusion In prostate cancer patients,the expression of claudin-4 and vascular E-cadherin is increased,and their abnormal expression deserves clinical attention.

关 键 词：前列腺癌 密封蛋白-4 血管黏附素蛋白 免疫组织化学染色 

分 类 号：R737.2[医药卫生—肿瘤]