石菖蒲防治阿尔茨海默病的作用机制研究进展  

Research progress on mechanism of action of Rhizoma Acori Tatarinowii in prevention and treatment of Alzheimer’s disease

作　　者：周悦 李威[2] 李海平[2] ZHOU Yue;LI Wei;LI Haiping(School of Clinical Medicine,Beihua University,Jilin Province,Jilin132013,China;Department of Neurology,Affiliated Hospital of Beihua University,Jilin Province,Jilin132001,China)

机构地区：[1]北华大学临床医学院,吉林吉林132013 [2]北华大学附属医院神经内科,吉林吉林132001

出　　处：《中国医药导报》2023年第27期64-67,共4页China Medical Herald

基　　金：吉林省教育厅科学技术研究项目(JJKH 20220066KJ)。

摘　　要：阿尔茨海默病(AD)是老年人进行性认知功能障碍的最常见原因。近年来,中药石菖蒲因其具有独特的优势,已经成为国内外研究的热点。目前石菖蒲改善认知的作用机制尚未研究透彻,其可能同时作用于多个靶点,从而保护神经元,改善神经元突触重塑,调控中枢胆碱能系统,抑制神经炎症,减少氧化应激和改善肠道微生态系统等。本文就近年来关于石菖蒲防治AD的作用机制研究进行系统归纳,以期为临床和实验研究提供参考依据。Alzheimer’s disease(AD)is the most common cause of progressive cognitive dysfunction in the elderly.In recent years,Rhizoma Acori Tatarinowii has become a research hotspot at home and abroad because of its unique advantages.At present,the mechanism of Rhizoma Acori Tatarinowii improving cognition has not been thoroughly studied,and it may act on multiple targets simultaneously,thereby protecting neurons,improving synaptic remodeling,regulating central cholinergic system,inhibiting neuroinflammation,reducing oxidative stress,and improving intestinal microecosystem.In order to provide reference for clinical and experimental studies,this paper systematically summarizes the mechanism of action of Rhizoma Acori Tatarinowii in preventing and treating AD in recent years.

关 键 词：阿尔茨海默病 石菖蒲 细辛醚 发病机制 

分 类 号：R742[医药卫生—神经病学与精神病学]