电-酶偶联催化转化CO_(2) 的研究进展  

Advances in electrocatalytic-enzymatic hybrid systems for CO_(2)reduction

作　　者：吕永琴[1] 苏海佳[1] 秦培勇[1] 陈必强[1] 谭天伟[1] LU Yongqin;SU Haijia;QIN Peiyong;CHEN Biqiang;TAN Tianwei(National Energy R&D Center for Biorefinery,Beijing Key Laboratory of Bioprocess,College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]北京化工大学、生命科学与技术学院、北京市生物加工过程重点实验室、国家能源生物炼制研发中心,北京100029

出　　处：《生物加工过程》2023年第5期471-484,563,共15页Chinese Journal of Bioprocess Engineering

摘　　要：实现对CO_(2)的高效资源化利用不仅可保障经济高质量发展,而且能助力实现“双碳”目标。生物催化转化CO_(2)是利用活细胞或酶作为催化剂,以CO_(2)为原料合成复杂有机分子的过程。生物酶催化剂具有选择性高、操作条件绿色温和以及易实现碳碳偶联等优点,有助于将CO_(2)转化为高附加值产品。但由于CO_(2)的高化学惰性,使得CO_(2)的活化和C O断键成为一个难题。受天然光合作用启发,研究人员提出了电酶偶联催化转化CO_(2)策略,即利用电化学体系,结合非固定化或固定化酶,利用电能驱动酶催化C O断键,并将CO_(2)转化为高附加值化合物。本文从NAD(P)H非依赖型和NAD(P)H依赖型氧化还原酶与电极之间的电子传递机制出发,重点阐述了酶与电极间的相互作用、电极的修饰方法和新型电酶耦合体系的研究进展,概述了电酶偶联用于CO_(2)催化转化所面临的主要挑战和未来发展前景。The effective utilization of carbon dioxide can not only assure high-quality economic development,but also play an important role in achieving the carbon peaking and carbon neutrality.With living cells or enzymes as catalysts,organisms can convert the substrate CO_(2)into complex organic molecules.Enzymatic catalysis has demonstrated the benefits of high selectivity,environmentally friendly operating conditions,as well as easy carbon-carbon coupling,which can facilitate the conversion of CO_(2)into high value-added products.However,the activation of CO_(2)has been a challenging task due to its high chemical inertness.Inspired by photosynthesis in nature,researchers proposed and developed the electro-enzymatic conversion of CO_(2).In this case,electrochemical system is combined with the use of non-immobilized or immobilized enzymes,so C O bonds can be broken with electrical energy and the subsequent enzymatic catalysis can produce high value-added chemicals.In this review,we started from the electron transfer mechanism between electrodes and NAD(P)H independent and NAD(P)H dependent enzymes,then discussed the interactions between enzymes and electrodes,electrode modification techniques,as well as the development of new electro-enzyme coupling systems.In addition,we listed the major challenges in this field and presented the prospects of these systems.

关 键 词：电催化 酶催化 耦合系统 CO_(2)还原 

分 类 号：Q819[生物学—生物工程] O644[理学—物理化学]