魔芋葡甘聚糖微球的制备和高值利用  

Preparation and high value utilization of konjac glucomannan microspheres

作　　者：周炜清[1,2,3] 李娟 那向明[1] 燕星燃[1] 李桐 马光辉 ZHOU Weiqing;LI Juan;NA Xiangming;YAN Xingran;LI Tong;MA Guanghui(State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;Key Laboratory of Biopharmaceutical Preparation and Delivery,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;College of Chemical Engineering,University of the Chinese Academy of Sciences,Beijing 101408,China)

机构地区：[1]中国科学院过程工程研究所生化工程国家重点实验室,北京100190 [2]中国科学院过程工程研究所,生物药制备与递送重点实验室(中国科学院),北京100190 [3]中国科学院大学化工学院,北京101408

出　　处：《生物加工过程》2023年第5期507-514,共8页Chinese Journal of Bioprocess Engineering

基　　金：国家重点研发计划(2021YFC2102802-4、2020YFA0112603)。

摘　　要：魔芋葡甘聚糖提取自魔芋根茎,是一种天然多糖,具有良好的亲水性、生物相容性和可降解性,是一种优良的生物材料,近年来受到广泛关注。葡甘聚糖目前仍处于初加工阶段,主要用作食品或食品添加剂,亟待发展新的高附加值应用方向。分离介质和细胞培养微载体是生物制品生产过程中必不可少的生物工程材料,但是市场仍主要被国外产品垄断,实现国产化有利于提升我国生物制品企业的竞争力,保障产业安全。本文综述了具有自主知识产权的葡甘聚糖微球及其制备工艺的建立、结构和表面性能调控,介绍了其在分离纯化、细胞/干细胞培养方面的应用,以期为开辟新的魔芋高值化应用提供参考。Konjac glucomannan,a natural polysaccharide extracted from konjac,can serve as an excellent biomaterial and has attracted widespread attention in the past decades due to its good hydrophilicity,biocompatibility,biodegradability,etc.Glucomannan is currently in the preliminary processing stage,and the development of new high value-added applications is still in demand.Separation media and cell culture microcarriers are essential bioengineering materials for the manufacture of biological products.Herein we reviewed the research on glucomannan microspheres with independent intellectual property rights,including the preparation technology,structure,and its surface performance regulation.In addition,we summarized their applications as separation media and cell/stem cell culture microcarriers,hoping to stimulate new ideas for the development of new high-value applications in konjac industry.

关 键 词：魔芋葡甘聚糖 微球 分离介质 细胞培养 微载体 

分 类 号：Q949.9[生物学—植物学] Q819