生物反应器气液传质强化的研究进展  

Research progress of gas-liquid mass transfer intensification in bioreactor

作　　者：黎兴燕 甘建 陈家俊 刘华宗 李干禄[1] 李辉 陈可泉[1] LI Xingyan;GAN Jian;CHEN Jiajun;LIU Huazong;LI Ganlu;LI Hui;CHEN Kequan(College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211800,China)

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211800

出　　处：《生物加工过程》2023年第5期564-573,共10页Chinese Journal of Bioprocess Engineering

基　　金：国家重点研发计划(2018YFA0901500);国家自然科学基金(U21B2097);江苏省先进生物制造创新中心专项课题。

摘　　要：生物反应器是生物过程工程的核心设备,应用广泛,已实现了巨大的经济价值,但仍然存在较低的气液传质效率,这是降低生物转化效率的关键因素。本文综述了生物反应器中基于溶质渗透模型的传质机制及常用的体积传质系数(k_(L)a)测量方法,剖析了气含率(Φ)、气泡直径(d B)、扩散系数(D_(L))、湍动能耗散率(ε)、液相密度(ρ)、流体黏度(μ)以及表面张力(σ)等因素对k_(L)a的影响机制,论述了最新的气液传质强化方法及应用进展,以期为生物反应器的气液传质强化提供研究思路。Bioreactor,as the core equipment for biological process engineering,is widely used in industry and has achieved great economic value.However,it still suffers from low gas-liquid mass transfer efficiency,which is the key factor for the overall efficiency of bioconversion.Herein,we reviewed the mechanism of mass transfer in bioreactors based on solute permeation model,as well as the commonly used measurement methods of volume mass transfer coefficient(k_(L)a).In addition,we discussed the influences of multiple factors on k_( L) a,including gas holdup(Φ),bubble diameter(d B),diffusion coefficient(D_(L)),turbulent kinetic energy dissipation(ε),liquid density(ρ),fluid viscosity(μ)and surface tension(σ).Finally,we presented the latest gas-liquid mass transfer intensification methods and application progress,which could be beneficial for further research regarding the gas-liquid mass transfer intensification of bioreactors.

关 键 词：生物反应器 传质强化 气液界面 体积传质系数 气液传质 

分 类 号：Q815[生物学—生物工程]