IGFBP1在鼻咽癌诊断及预后中的价值  

The value of IGFBP1 in the diagnosis and prognosis of nasopharyngeal carcinoma

作　　者：罗芸 黄彬亮 黄旭纯 许镒洧[1,2] 伍方财[4] Luo Yun;Huang Binliang;Huang Xuchun;Xu Yiwei;Wu Fangcai(Department of Clinical Laboratory,Cancer Hospital Affiliated to Shantou University Medical School,Shantou 515041,China;Precision Medicine Center,Shantou University Medical School,Shantou 515041,China;Department of Clinical Laboratory,Yongchuan Hospital Affiliated to Chongqing Medical University,Chongqing 402160,China;Department of Radiotherapy,Cancer Hospital Affiliated to Shantou University Medical School,Shantou 515041,China)

机构地区：[1]汕头大学医学院附属肿瘤医院检验科,汕头515041 [2]汕头大学医学院精准医学中心,汕头515041 [3]重庆医科大学附属永川医院检验科,重庆402160 [4]汕头大学医学院附属肿瘤医院放疗科,汕头515041

出　　处：《中国医师杂志》2023年第9期1329-1332,1339,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(81972801);广东省科技创新战略专项(STKJ202209069)。

摘　　要：目的探索胰岛素样生长因子结合蛋白1(IGFBP1)在鼻咽癌(NPC)诊断及预后中的作用,寻找可用于鼻咽癌诊断的分子标志物。方法回顾性分析汕头大学医学院附属肿瘤医院150例NPC患者(就诊时间2014年4月至2015年5月)以及同期143例健康体检者(正常对照组)的临床基线资料。采用酶联免疫吸附实验(ELISA)检测训练队列112例鼻咽癌患者和109例正常对照者的血清IGFBP1浓度,并在验证队列中(38例鼻咽癌患者,34例正常对照者)进行验证。采用受试者工作特征曲线(ROC)评估血清IGFBP1诊断鼻咽癌的价值。结果在训练队列和验证队列中,相比正常对照组,鼻咽癌患者血清IGFBP1的表达水平更高(均P<0.05)。在训练队列中,ROC曲线下面积为0.768(95%CI:0.706~0.830),诊断特异度和灵敏度分别为90.83%和48.21%。在验证队列中,ROC曲线下面积为0.798(95%CI:0.697~0.899),诊断特异度和灵敏度分别为97.06%和31.58%。两个队列的阳性病例预测值均>80%,阴性预测值>50%。两个队列的血清IGFBP1诊断临界值都是1077 ng/ml。结论IGFBP1有作为鼻咽癌诊断分子标志物的应用价值。Objective To explore the role of insulin-like growth factor binding protein 1(IGFBP1)in the diagnosis and prognosis of nasopharyngeal carcinoma(NPC),and to search for molecular markers that can be used for the diagnosis of NPC.Methods A retrospective analysis was conducted on 150 NPC patients(treated from April 2014 to May 2015)at the Cancer Hospital Affiliated to Shantou University Medical School,and clinical baseline data were collected from 143 healthy individuals(normal control group)during the same period.The serum IGFBP1 concentration was detected using enzyme-linked immunosorbent assay(ELISA)in 112 nasopharyngeal carcinoma patients and 109 normal controls in the training cohort,and was validated in the validation cohort(38 nasopharyngeal carcinoma patients and 34 normal controls).The diagnostic value of serum IGFBP1 in nasopharyngeal carcinoma was evaluated using the receiver operating characteristic curve(ROC).Results Compared to the normal control group,the expression level of serum IGFBP1 in nasopharyngeal carcinoma patients was higher in the training and validation queues(all P<0.05).In the training queue,the area under the ROC curve was 0.768(95%CI:0.706-0.830),with diagnostic specificity and sensitivity of 90.83%and 48.21%,respectively.In the validation queue,the area under the ROC curve was 0.798(95%CI:0.697-0.899),with diagnostic specificity and sensitivity of 97.06%and 31.58%,respectively.The predictive values for positive cases in both cohorts were greater than 80%,while the predictive values for negative cases were greater than 50%.The diagnostic threshold for serum IGFBP1 in both cohorts was 1077 ng/ml.Conclusions IGFBP1 has practical value as a molecular marker for the diagnosis of nasopharyngeal carcinoma.

关 键 词：胰岛素样生长因子结合蛋白质1 鼻咽肿瘤 生物标记 肿瘤 

分 类 号：R739.63[医药卫生—肿瘤]