FANCD2的作用机制及其在肿瘤中的研究进展  

The function mechanism of FANCD2 and its research progress in tumors

作　　者：张黎明 王丽娜 王少强 Zhang Liming;Wang Lina;Wang Shaoqiang(Clinical Medicine School,Jining Medical University,Jining 272000,China;Medical Research Center,Affiliated Hospital of Jining Medical University,Jining 272029,China;Department of Thoracic Surgery,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,济宁272000 [2]济宁医学院附属医院医学研究中心,济宁272029 [3]济宁医学院附属医院胸外科,济宁272029

出　　处：《中国医师杂志》2023年第9期1414-1418,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(81802290,81800182);山东省自然科学基金(ZR2018BH020)。

摘　　要：范可尼贫血(FA)是一种常染色体隐性遗传性疾病,也是最常见的遗传性骨髓衰竭综合征,可导致骨髓衰竭、罹患癌症的风险增加以及发育异常。FANCD2是FA基因家族中的一员,已成为FA信号传导的焦点。研究发现,FANCD2在肿瘤的发生发展中发挥重要作用并能够作为铁死亡(ferroptosis)的相关基因参与调节铁死亡。本文对FANCD2的作用机制及其在肿瘤中的研究进展进行综述,以期为疾病的诊断和治疗提供新的方向和思路。Fanconi anemia(FA)is an autosomal recessive inherited disease and the most common hereditary bone marrow failure syndrome,which can lead to bone marrow failure,increased risk of cancer,and developmental abnormalities.FANCD2 is a member of the FA gene family and has become the focal point of FA signaling.Research has found that FANCD2 plays an important role in the occurrence and development of tumors and can participate in regulating ferroptosis as a related gene.This article reviews the mechanism of action of FANCD2 and its research progress in tumors,in order to provide new directions and ideas for the diagnosis and treatment of diseases.

关 键 词：范可尼贫血互补群蛋白质D2 肿瘤 DNA损伤 铁死亡 

分 类 号：R730.2[医药卫生—肿瘤]