复方海蛇胶囊联合重复经颅磁刺激治疗轻度认知功能障碍对患者生活能力的改善探讨  

Study on the improvement of living ability of patients with mild cognitive impairment treated by compound sea snake capsule combined with repeated transcranial magnetic stimulation

作　　者：周传义 陈婷婷 ZHOU Chuan-yi;CHEN Ting-ting(Department of Neurology,the Fourth People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市第四人民医院神经内科,252000

出　　处：《中国现代药物应用》2023年第17期39-42,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究轻度认知功能障碍患者联合应用重复经颅磁刺激与复方海蛇胶囊治疗对其生活能力的改善作用。方法60例轻度认知功能障碍患者,依据随机数字表法分为对照组与观察组,各30例。对照组实施复方海蛇胶囊治疗,观察组实施重复经颅磁刺激与复方海蛇胶囊联合治疗。比较两组治疗效果,治疗前后认知功能、记忆能力和生活能力、血清学指标[S-100钙结合蛋白B(S-100B)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)]水平。结果观察组治疗总有效率93.33%高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,两组简易智力状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评分均高于本组治疗前,且观察组MMSE和MoCA评分分别为(28.73±2.90)、(29.12±1.13)分,高于对照组的(25.35±2.76)、(25.82±1.79)分,差异均有统计学意义(P<0.05)。治疗后,两组日常生活能力评分和Rivermead行为记忆试验(RBMT)评分均优于本组治疗前,且观察组日常生活能力评分和RBMT评分分别为(23.82±1.80)、(22.72±1.35)分,优于对照组的(25.25±1.66)、(20.64±1.19)分,差异均有统计学意义(P<0.05)。治疗后,两组S-100B、NSE、MBP水平均低于本组治疗前,且观察组S-100B(276.36±66.33)pg/ml、NSE(24.17±5.29)ng/ml、MBP(88.35±25.17)pg/ml低于对照组的(387.26±68.95)pg/ml、NSE(33.68±5.74)ng/ml、MBP(121.36±27.55)pg/ml,差异均有统计学意义(P<0.05)。结论轻度认知功能障碍患者联合应用重复经颅磁刺激与复方海蛇胶囊治疗可获得显著效果,有利于改善患者认知功能、记忆能力以及生活能力,同时可促进患者各项血清学指标恢复,建议临床推广应用。Objective To investigate the improvement of living ability of patients with mild cognitive impairment treated by compound sea snake capsule combined with repeated transcranial magnetic stimulation.Methods A total of 60 patients with mild cognitive impairment were divided into control group and observation group according to the random numerical table,with 30 cases in each group.The control group was treated with compound sea snake capsule,and the observation group was treated with repeated transcranial magnetic stimulation and compound sea snake capsule.Both groups were compared in terms of therapeutic effect,and cognitive function,memory ability,living ability,and levels of serological indicators[S-100 protein B(S-100B),neuron-specific enolase(NSE),myelin basic protein(MBP)]before and after treatment.Results The total effective rate of the observation group was 93.33%,which was higher than that of 73.33%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of Minimental State Examination(MMSE)and the Montreal Cognitive Assessment Scale(MoCA)in both groups were higher than those before treatment in this group;the scores of MMSE and MoCA in the observation group were(28.73±2.90)and(29.12±1.13)points,which were higher than those of(25.35±2.76)and(25.82±1.79)points in the control group;the differences were statistically significant(P<0.05).After treatment,the scores of Activities of Daily Living and Rivermead Behavioral Memory Test(RBMT)in both groups were better than those before treatment in this group;the scores of Activities of Daily Living and RBMT in the observation group were(23.82±1.80)and(22.72±1.35)points,which were better than those of(25.25±1.66)and(20.64±1.19)points in the control group;the differences were statistically significant(P<0.05).After treatment,S-100B,NSE and MBP levels in both groups were lower than those before treatment in this group;the observation group had S-100B of(276.36±66.33)pg/ml,NSE of(24.17±5.29)ng/ml and MBP of(88.35�

关 键 词：复方海蛇胶囊 重复经颅磁刺激 轻度认知功能障碍 生活能力 认知功能 

分 类 号：R749.1[医药卫生—神经病学与精神病学]