万古霉素鞘内注射治疗对颅内感染患者神经功能及临床恢复情况的影响  

Effects of intrathecal injection of vancomycin on neurological function and clinical recovery in patients with intracranial infection

作　　者：王芬 陈嘉曦 WANG Fen;CHEN Jia-xi(Preparation Department,The First Affiliated Hospital of Xiamen University,Xiamen 361000,China)

机构地区：[1]厦门大学附属第一医院制剂科,361000

出　　处：《中国现代药物应用》2023年第17期104-107,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析万古霉素注射治疗对颅内感染患者神经功能及临床恢复情况的影响。方法90例颅内感染患者为研究对象,依据万古霉素给药方式差异分为观察组和对照组,各45例。对照组采用万古霉素静脉滴注治疗,观察组采用万古霉素鞘内注射治疗。比较两组患者疗效,治疗前后神经功能缺损评分、日常生活能力评分及临床指标。结果观察组治疗总有效率97.78%明显高于对照组的86.67%,差异有统计学意义(P<0.05)。治疗后,两组神经功能缺损评分、日常生活能力评分均优于本组治疗前,且观察组神经功能缺损评分、日常生活能力评分分别为(8.13±1.15)、(82.28±5.27)分,均优于对照组的(13.26±1.19)、(71.36±4.65)分,差异有统计学意义(P<0.05)。治疗后,两组白细胞计数、白细胞介素-6、C反应蛋白、颅内压、脑脊液蛋白水平均优于本组治疗前,且观察组白细胞计数(4.14±0.95)×10^(9)/L、白细胞介素-6(9.36±1.09)ng/L、C反应蛋白(8.34±1.05)mg/L、颅内压(2.06±0.07)kPa、脑脊液蛋白(0.29±0.10)g/L均优于对照组的(9.09±1.82)×10^(9)/L、(12.47±1.52)ng/L、(12.64±1.13)mg/L、(2.45±0.09)kPa、(0.41±0.12)g/L,差异有统计学意义(P<0.05)。结论万古霉素鞘内注射治疗对颅内感染患者神经功能及临床恢复具有非常积极的影响,显著优于传统静脉滴注方式。Objective To analyze the effects of intrathecal injection of vancomycin on neurological function and clinical recovery in patients with intracranial infection.Methods A total of 90 patients with intracranial infection were studied and divided into observation group and control group according to the difference of vancomycin administration,with 45 cases in each group.The control group was treated with intravenous vancomycin,and the observation group was treated with intrathecal vancomycin.The efficacy,scores of neurological deficit and activities of daily living,and clinical indexes before and after treatment were compared between the two groups.Results The total effective rate in the observation group was 97.78%,which was significantly higher than that of 86.67%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of neurological deficit and activities of daily living in both groups were better than those before treatment in this group.the scores of neurological deficit and activities of daily living in the observation group were(8.13±1.15)and(82.28±5.27)points,which were better than those of(13.26±1.19)and(71.36±4.65)points in the control group;the differences were statistically significant(P<0.05).After treatment,the white blood cell count,interleukin-6,C-reactive protein,intracranial pressure and cerebrospinal fluid protein levels in both groups were better than those before treatment in this group;in the observation group,the white blood cell count was(4.14±0.95)×10^(9)/L,the interleukin-6 was(9.36±1.09)ng/L,the C-reactive protein was(8.34±1.05)mg/L,the intracranial pressure was(2.06±0.07)kPa and the cerebrospinal fluid protein was(0.29±0.10)g/L,which were better than those of(9.09±1.82)×10^(9)/L,(12.47±1.52)ng/L,(12.64±1.13)mg/L,(2.45±0.09)kPa and(0.41±0.12)g/L in the control group;the differences were statistically significant(P<0.05).Conclusion Intrathecal injection of vancomycin has a very positive effect on the neurological function and c

关 键 词：万古霉素 颅内感染 鞘内注射 神经功能 临床恢复 

分 类 号：R742.9[医药卫生—神经病学与精神病学]