血栓通注射液联合丁苯酞氯化钠注射液治疗急性脑梗死临床研究  

Clinical Study on Xueshuantong Injection Combined with Butylphthalide and Sodium Chloride Injection for Acute Cerebral Infarction

作　　者：曾瑞琦 孙如[1] 张徐枫 ZENG Ruiqi;SUN Ru;ZHANG Xufeng(Department of Neurological,The First People's Hospital of Huzhou,Huzhou Zhejiang 313000,China)

机构地区：[1]湖州市第一人民医院神经内科,浙江湖州313000

出　　处：《新中医》2023年第15期59-63,共5页New Chinese Medicine

摘　　要：目的:观察血栓通注射液联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效。方法:采用分层抽样法将52例急性脑梗死患者分为2组各26例,对照组采用丁苯酞氯化钠注射液治疗,研究组使用血栓通注射液联合丁苯酞氯化钠注射液治疗。比较2组临床疗效、不良反应发生率,比较2组治疗前后血清炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-23(IL-23)、超敏C-反应蛋白(hs-CRP)],脑血流动力学指标[平均血流量(Qm)、平均血流速度(Vm)、外周阻力(TPR)、动态阻力(DR)]及美国国立卫生研究院卒中量表(NIHSS)评分、巴氏指数评估量表(BI)评分。结果:研究组治疗总有效率88.46%,高于对照组61.54%(P<0.05)。治疗前,2组血清TNF-α、IL-6、IL-23、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,2组血清TNF-α、IL-6、IL-23、hs-CRP水平均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗前,2组NIHSS、BI评分比较,差异无统计学意义(P>0.05);治疗后,2组NIHSS评分均降低(P<0.05),BI评分均升高(P<0.05),且研究组NIHSS评分低于对照组(P<0.05),BI评分高于对照组(P<0.05)。治疗前,2组Qm、Vm、TPR、DR水平比较,差异无统计学意义(P>0.05);治疗后,2组Qm、Vm水平均升高(P<0.05),TPR、DR水平均降低(P<0.05),且研究组Qm、Vm水平高于对照组(P<0.05),TPR、DR水平低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血栓通注射液联合丁苯酞氯化钠注射液治疗急性脑梗死患者安全有效,可明显缓解炎症反应,改善神经功能。Objective:To observe the clinical effect of Xueshuantong Injection combined with Butylphthalide and Sodium Chloride Injection for acute cerebral infarction.Methods:A total of 52 cases of acute cerebral infarction were divided into two groups according to the stratified sampling method,with 26 cases in each group.The control group was treated with Butylphthalide and Sodium Chloride Injection,and the study group was treated with Xueshuantong Injection combined with Butylphthalide and Sodium Chloride Injection.The clinical effects and the incidence of adverse reactions were compared between the two groups.Before and after treatment,serum inflammatory indexes[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-23(IL-23),hypersensitive C-reactive protein(hs-CRP)],cerebral hemodynamic indexes[mean blood flow(Qm),mean blood velocity(Vm),total peripheral resistance(TPR),dynamic resistance(DR)],National Institutes of Health Stroke Scale(NIHSS)scores,and Barthel Index(BI)scores were compared between the two groups.Results:The total effective rate of treatment was 88.46%in the study group,higher than that of 61.54%in the control group(P<0.05).Before treatment,there were no significant differences being found the comparison of the levels of TNF-α,IL-6,IL-23,and hs-CRP in serum between the two groups(P>0.05).After treatment,the levels of TNF-α,IL-6,IL-23,and hs-CRP in serum in the two groups were decreased(P<0.05),and the above levels in the study group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found the comparison of the scores of NIHSS and BI between the two groups(P>0.05).After treatment,NIHSS scores were decreased(P<0.05),and BI scores were increased in both groups(P<0.05);NIHSS score in the study group was lower than that in the control group(P<0.05),and BI score was higher than that in the control group(P<0.05).Before treatment,there was no significant difference being found the comparison of the levels of Qm,Vm,TPR,and DR between the two

关 键 词：急性脑梗死 血栓通注射液 丁苯酞氯化钠注射液 炎症指标 脑血流动力学指标 

分 类 号：R743.3[医药卫生—神经病学与精神病学]