Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis  

作　　者：Anitha Roy Vasantha Mallenahalli Neelakantappa Jayashree Ganesan Balakrishnan Ramajayam Asokan Srinivasan Kulandaivel V.V.Sathibabu Uddandrao Sengottuvelu Singaravel 

机构地区：[1]Center for Transdisciplinary Research,Department of Pharmacology,Saveetha Dental College and Hospitals,Saveetha Institute of Medical and Technical Sciences,Chennai,Tamil Nadu,India-600077 [2]Department of Pharmacology,Kasturba Medical College,Mangolore,Manipal Academy of Higher Education,Manipal,India-5750013 [3]Department of Pharmacology,Aarupadai Veedu Medical College&Hospital,Vinayaka Mission Research Foundation,Puducherry,India-607403 [4]Department of Pharmaceutical Chemistry,Nandha College of Pharmacy,Erode,Tamilnadu,India-638052 [5]Department of Biochemistry,K.S.Rangasamy College of Arts and Science(Autonomous),Tiruchengode,Namakkal District,Tamilnadu,India-637215 [6]Department of Pharmacology,Nandha College of Pharmacy,Erode,Tamil Nadu,India-638052

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第9期384-392,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To investigate the cardioprotective effect of beta-glucan against isoproterenol-induced cardiotoxicity in rats,and elucidate the underlying mechanism.Methods:Rats were orally pretreated with beta-glucan(40 mg/kg body weight)for 30 d,and isoproterenol(20 mg/100 g body weight)was administered on days 31 and 32.The effects of beta-glucan on markers of cardiac injury,hemodynamic changes,production of proinflammatory cytokines,and the corresponding mRNA expressions were evaluated.In addition,histological analysis was performed.Results:Pretreatment with beta-glucan prevented isoproterenol-induced cardiac injury by preserving the structural and functional integrity of the plasma membrane and attenuating the production of proinflammatory cytokines(NF-κB,TNF-α,IL-6,IL-1β,and IFN-γ)in the heart.Moreover,beta-glucan significantly downregulated the mRNA expression of ACE,AT1R,TNF-α,IL-6,NF-κB,caspase-3,TLR-4,and Bax,and upregulated Bcl-2 in the heart.At the same time,pretreatment with beta-glucan alleviated myocardial damage as reflected in a reduction in myonecrosis,edema,and erythrocyte extravasation with almost imperceptible inflammation.Conclusions:Beta-glucan can protect against isoproterenol-induced cardiotoxicity by attenuating cardiac inflammation and apoptosis and regulating the ACE-AT1R axis,thereby preventing cardiac remodeling.

关 键 词：Βeta-glucan ISOPROTERENOL Cardiac inflammation Cardiac apoptosis Cardiovascular diseases Heart failure Myocardial infarction 

分 类 号：R542.2[医药卫生—心血管疾病]