Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-MSH-stimulated B16F10 murine melanoma cells  

作　　者：Xian-Rong Zhou Jung Hwan Oh Fatih Karadeniz Hyunjung Lee Hyo Eun Kim Migeon Jo Youngwan Seo Chang-Suk Kong 

机构地区：[1]Department of Bioscience,Silla University,Busan 46958,Korea [2]Collaborative Innovation Center for Child Nutrition and Health Development,Chongqing University of Education,Chongqing 400067,China [3]Marine Biotechnology Center for Pharmaceuticals and Foods,Silla University,Busan 46958,Korea [4]Nutritional Education,Graduate School of Education,Silla University,Busan 46958,Korea [5]Department of Food and Nutrition,Silla University,Busan 46958,Korea [6]Division of Convergence on Marine Science,Korea Maritime and Ocean University,Busan 49112,Korea

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第9期403-410,共8页亚太热带生物医学杂志（英文版）

基　　金：This work was supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2023R1A2C1006268 and RS-2023-00212560).

摘　　要：Objective:To explore the anti-melanogenic potential of Cyrtomium falcatum.Methods:The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity,melanin content,and the expressions of melanogenesis-related genes and proteins were analyzed inα-melanocyte-stimulating hormone(α-MSH)-stimulated B16F10 cells.Results:α-MSH treatment significantly increased tyrosinase activity,and extracellular and intracellular melanin content,as well as the expression levels of tyrosinase,microphthalmia-associated transcription factor(MITF),tyrosinase-related protein(TRP)-1,and TRP-2 in B16F10 cells.Treatment with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase,MITF,TRP-1,and TRP-2 in a dose-dependent manner.Conclusions:Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.

关 键 词：Cyrtomium falcatum MELANOGENESIS Α-MSH B16F10 melanoma cells 

分 类 号：R285[医药卫生—中药学]