自贡地区健康体检中老年人群阿尔茨海默病患病调查及AD7C-NTP的相关性分析  

Investigation on the prevalence of Alzheimer's Disease and Correlation Analysis of AD7CNTP in Middle-Aged and Elderly People Undergoing Physical Examination in Zigong Area

作　　者：郑戈[1] 毕兵 朱晶 郭久畅 Zheng Ge;Bi Bing;Zhu Jing;Guo Jiu-chang(Zigong City People’s Hospital Health Management Center,Zigong Sichuan 643000,China)

机构地区：[1]自贡市第一人民医院健康管理中心,四川自贡643000

出　　处：《中华养生保健》2023年第20期90-93,共4页CHINESE HEALTH CARE

基　　金：2021年自贡市重点科技计划任务(2021YLSF04)。

摘　　要：目的探讨自贡地区健康体检中老年人群阿尔茨海默病患病调查及AD7C-NTP的相关性。方法选取2021年1月—2022年6月在自贡市第一人民医院进行健康体检的1460人为研究对象,除进行常规体检外,同时进行阿尔茨海默病相关神经丝蛋白(AD7c-NTP)检测。根据AD7c-NTP结果,最后筛选出尿AD7C-NTP异常升高的受试者,分为AD7C-NTP正常组(n=1250)和AD7C-NTP升高组(n=210),收集两组血液生化指标数据进行对比,同时对高AD7c-NTP人群通过简易智力状态检查(MMSE)以及MRI进行中阿尔茨海默病筛查,并根据临床痴呆评定量表(CDR),分析不同程度AD其AD7C-NTP水平的差异性。结果1460名体检者中尿液AD7c-NTP异常升高达210人,占比14.38%。AD7c-NTP异常升高人群与正常人群血清Cr、TBIL、GLU、TC、LDL比较,差异均有统计学意义(P<0.05);在210例高AD7C-NTP水平人群中AD确诊为152例(72.38%),不同认知功能障碍的AD患者其AD7CNTP水平比较,差异有统计学意义(P<0.05);AD7c-NTP水平与Cr、GLU、TC、LDL存在正相关性(P<0.05),与MMSE呈负相关,与TBIL无明显相关(P>0.05)。结论AD7c-NTP水平与认知功能存在相关性,可以作为早期筛查AD的辅助方法之一;AD7c-NTP水平与Cr、GLU、TC、LDL存在相关性,高Cr、GLU、TC、LDL是AD发病的危险因素之一。Objective To investigate the prevalence of Alzheimer’s disease and the correlation between AD7C-NTP in middleaged and elderly people undergoing physical examination in Zigong area.Methods From January 2021 to June 2022,1460 subjects were selected to undergo physical examinations in the Health Management Department of the First People’s Hospital of Zigong City.In addition to routine physical examination,1460 patients were also tested for Alzheimer’s disease related neurofilament protein AD7c-NTP.Based on the results of AD7c-NTP,subjects with abnormally elevated urinary AD7CNTP were selected and divided into normal AD7C-NTP group(n=1250)and AD7C-NTP-elevated group(n=210).Blood biochemical index data were collected and compared between the two groups.At the same time,people with high AD7c-NTP were screened for Alzheimer’s disease through simple mental state examination(MMSE)and MRI,and according to the Clinical Dementia Rating Scale(CDR).Analyze the diff erences in AD7C-NTP levels in diff erent degrees of AD.Results Among the 1460 examinees,there were 210 cases with abnormal increase in urine AD7c-NTP,accounting for 14.38%.There were diff erences in serum Cr,TBIL,GLU,TC,and LDL between individuals with abnormal AD7c-NTP elevation and normal individuals(P<0.05);Among the 210 individuals with high AD7C-NTP levels,152(72.38%)were diagnosed with AD,and there were diff erences in AD7C-NTP levels among AD patients with diff erent cognitive impairments(P<0.05);The level of AD7c-NTP is positively correlated with Cr,GLU,TC,and LDL(P<0.05),negatively correlated with MMSE,and not signifi cantly correlated with TBIL(P>0.05).Conclusion There is a correlation between AD7c-NTP levels and cognitive function,which can be used as one of the auxiliary methods for early screening of AD;The level of AD7c-NTP is correlated with Cr,GLU,TC,and LDL,and high Cr,GLU,TC,and LDL are one of the risk factors for the onset of AD.

关 键 词：自贡地区 健康体检 阿尔茨海默病 调查 AD7C-NTP 相关性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]