GSDME在恶性肿瘤中的研究现状  

Current status of GSDME research in malignant tumors

作　　者：张渊 冯勤梅[2] 马梅杰 白芷玉 李琪[1] Zhang Yuan;Feng Qinmei;Ma Meijie;Bai Zhiyu;Li Qi(Fifth School of Clinical Medicine of Shanxi Medical University,Taiyuan 030000,China;Department of Obstetrics and Gynecology,Shanxi Provincial People's Hospital,Taiyuan 030000,China)

机构地区：[1]山西医科大学第五临床医学院,太原030000 [2]山西省人民医院妇产科,太原030000

出　　处：《国际肿瘤学杂志》2023年第5期285-289,共5页Journal of International Oncology

摘　　要：细胞焦亡是一种区别于凋亡和坏死的细胞程序性死亡,其发生过程伴随着细胞膜的裂解和细胞内容物的释放。细胞焦亡由Gasdermin蛋白家族介导发生,并且依赖于caspase的活性。GSDME是Gasdermin蛋白超家族的重要成员之一,在其介导的细胞焦亡中依赖于caspase-3的活性。近年来,随着对细胞焦亡的进一步研究,GSDME诱导细胞焦亡的机制逐渐明确。众多研究表明GSDME介导的细胞焦亡在肿瘤的发生发展及化疗耐药中起重要作用。然而GSDME介导的细胞焦亡没有特异性,在诱导肿瘤细胞焦亡的同时,可诱导机体的正常细胞发生焦亡,从而对机体的各个器官造成不同程度的损伤。深入研究GSDME诱导细胞焦亡的机制、GSDME在恶性肿瘤中的作用及其化疗不良反应,可为肿瘤的监测、治疗及判断预后提供新的思路。Pyroptosis is a type of programmed cell death distincted from apoptosis and necrosis,which is accompanied by the lysis of cell membranes and the release of cell contents.Pyroptosis occurs as mediated by Gasdermin protein family and is dependent on the activity of caspase.GSDME is one of the most important members of the Gasdermin protein superfamily.GSDME-mediated pyroptosis relies on the activity of caspase-3.In recent years,with further research on pyroptosis,the mechanism of GSDME-induced pyroptosis is becoming clear.Numerous studies have shown that GSDME-mediated pyroptosis plays an important role in the occurrence and development of tumors,as well as chemotherapy resistance.However,GSDME-mediated pyroptosis has no specificity and can induce pyroptosis of normal cells in the body while inducing tumor cell pyroptosis,thus causing different degrees of damage to various organs of the body.Further study on the mechanism of GSDME-induced pyroptosis,the role of GSDME in malignant tumors and the adverse reactions of chemotherapy can provide new ideas for tumor monitoring,treatment and prognosis judgment.

关 键 词：肿瘤 GSDME 细胞焦亡 

分 类 号：R730.2[医药卫生—肿瘤]