MKK3/6在p38MAPK信号转导通路介导的炎性反应中的作用:文献综述  

Role of MKK3/6 in inflammatory response mediated by p38MAPK signal transduction pathway

作　　者：师文静 王彩霞[1] 王莹[1] 李霄 Shi Wenjing;Wang Caixia;Wang Ying;Li Xiao(Department of Anesthesiology,Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot City,Inner Mongolia Autonomous Region,Inner Mongolia Autonomous Region 010030,China)

机构地区：[1]内蒙古医科大学第二附属医院手术麻醉中心,呼和浩特市010030

出　　处：《中华疼痛学杂志》2023年第4期689-694,共6页Chinese Journal Of Painology

摘　　要：p38MAPK信号转导通路是细胞信息传递的交汇点和共同通路,MAPK信号通路参与多种生理病理过程,尤其是参与调控炎性反应的最重要的信号系统。MKK3/6作为p38MAPK信号转导通路上游重要的激活因子,在炎性反应的过程中发挥着重要的作用。而炎性反应最终会导致炎性疼痛的发生。因此,在这篇综述中,总结讨论了当前对MKK3/6的理解和认识,以便为将来炎性疼痛领域的研究提供借鉴。p38MAPK signal transduction pathway is the junction and common pathway of cell signaling,and plays an important role in MAPK signal pathway and participates in many physiological and pathological processes.It is considered to be the most important signal system in regulating the inflammatory response in particular.MKK3/6,as an important upstream activator of p38MAPK signal transduction pathway,plays an important role in inflammatory response in particular.In this review,the current understanding of MKK3/6 is discussed in order to provide reference for future research in the field of inflammatory pain.

关 键 词：丝裂原激活蛋白激酶激酶类 炎性反应 炎性疼痛 

分 类 号：R364.5[医药卫生—病理学]