Ceftazidime exhibits a broad inhibition to the infection of SARS-CoV-2 prototype and Omicron variant in vitro by blocking spike protein-ACE2 interaction  

作　　者：Yun-zhe Zheng Zhao-yuan Liu Yue Li Xiao-ying Lv Yi Wu Meng-wen Huang Xing-chao Pan Jian-feng Chen Chang-dong Lin 

机构地区：[1]State Key Laboratory of Cell Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai,200031,China [2]Fundamental Research Center,Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),School of Life Sciences and Technology,Tongji University,Shanghai,200092,China [3]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,310024,China [4]Frontier Science Center for Stem Cell Research,Tongji University,Shanghai,200092,China

出　　处：《Acta Pharmacologica Sinica》2023年第9期1932-1934,共3页中国药理学报（英文版）

基　　金：supported by grants from National Key Research and Development Program of China (2020YFA0509000);National Natural Science Foundation of China (31830112,32030024,31525016 to JFC,32170769,31970702 to CDL);Shanghai Rising-Star Program (21QA1409700);Program of Shanghai Academic Research Leader (19XD1404200);Personalized Medicines-Molecular Signature-based Drug Discovery and Development,the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12010101);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2020266);the Young Elite Scientist Sponsorship Program by CAST (2019QNRC001);National Ten Thousand Talents Program,and the Fundamental Research Funds for the Central Universities (22120220378,22120220499).

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has coexisted with human beings over 3 years.It has undergone considerable evolution and several variants of concern(VOCs),including Alpha,Beta,Gamma,Delta and Omicron,have been classified by the World Health Organization(WHO).

关 键 词：ACE2 acute respiratory 

分 类 号：R737.14[医药卫生—肿瘤]