植入式多模态神经接口前沿进展  

Frontiers of Implantable Multimodal Neural Interfaces

作　　者：徐明亮 李芳媛 刘岳圻 张瑾慧 师亚洲 何飞[1,4] Xu Mingliang;Li Fangyuan;Liu Yueqi;Zhang Jinhui;Shi Yazhou;He Fei(Innovation and Integration Center of New Laser Technology,Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China;School of Physical Sciences,University of Science and Technology of China,Hefei 230026,Anhui,China;University of Chinese Academy of Sciences,Beijing 100049,China;Zhangjiang Laboratory,Shanghai 201210,China)

机构地区：[1]中国科学院上海光学精密机械研究所激光新体系融合创新中心,上海201800 [2]中国科学技术大学物理学院,安徽合肥230026 [3]中国科学院大学,北京100049 [4]张江实验室,上海201210

出　　处：《中国激光》2023年第15期147-174,共28页Chinese Journal of Lasers

摘　　要：神经接口是神经系统与外界物理设备进行信息交互的关键器件,利用光、电、磁、声等多种模态信息的融合,以神经信息增强的形式,可对大脑网络进行高时空精度的神经动力学分析,植入式多模态神经接口在神经科学基础研究、神经疾病的生物光电子诊疗、脑机融合与交互等前沿领域中具有重要应用.首先介绍了最新基于光学方法和电生理技术的多模态神经记录和调控原理,接着回顾了光电神经探针研究进展,并归纳了光学成像和记录及电生理记录等多种模态神经数据分析处理的一般方法,最后对植入式多模态神经接口进行总结,展望了该领域当前面临的挑战和未来的发展趋势.Significance The nervous system is composed of different types of neurons connected in a network.Neurons communicate with each other through electrochemical signals,and this dynamic interaction of neurons is the internal driving force of human perception,cognition,and behavior.Deciphering and understanding the meaning of various complex neural activities is of great significance in the frontiers of neurological disease diagnosis and treatment,neurological rehabilitation,fundamental brain science,and several braincomputer interface applications.To achieve this,it is critical to develop advanced neural interfaces capable of interacting with the dynamic neural activities and nervous system.Fundamental research in this field has rapidly increased over the past few decades as a result of advancements in neuroscience and neurotechnology.This research includes the development of innovative neural recording and modulation tools that have provided researchers with an early glimpse into previously unanswerable questions,such as determining how the mind works,or which have been recognized and funded by a host of initiatives.In recent years,the United States,European countries,Japan,and China have launched their own brain initiatives to support this emerging field.In the future,in order to completely understand the complex structural and functional nervous system,more powerful tools must be developed to record,transmit,and modulate signals using multiple approaches.These tools must have the ability to manipulate neuron cell types specifically while minimizing side effects such as“the observer effect.”Neurological disorders affect more than one billion people worldwide,accounting for 7%of the total global disease burden,and this number is expected to increase substantially as human life expectancy increases and with increased population aging.This is largely due to neuropsychiatric diseases(including Alzheimer s disease,Parkinson s disease,epilepsy,and so on)and cerebrovascular diseases,which impose a heavy burden on soci

关 键 词：医用光学 生物医学成像 光电子学 光遗传学 脑血流动力学 神经接口 植入式器件 微纳加工 

分 类 号：TN29[电子电信—物理电子学]