新型冠状病毒感染中医药临床研究:证据现状、问题与挑战  

Clinical research of traditional Chinese medicine for COVID-19:evidence,issues and challenges

作　　者：刘建平[1] LIU Jianping(Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029)

机构地区：[1]北京中医药大学循证医学中心,北京100029

出　　处：《现代中医临床》2023年第4期12-16,共5页Modern Chinese Clinical Medicine

基　　金：国家重点研发计划项目(No.2018YFE102300)。

摘　　要：在既往新型冠状病毒感染(简称“新冠感染”)大流行的3年中,中医药从疫情初始便介入了对新冠感染的防控和临床救治,取得令人瞩目的成就。本文总结了中医药预防和治疗新冠感染及其后遗症的临床科研证据的现状及存在问题,并提出紧急公共卫生流行事件下中医药研究的策略,力求为今后疫病的中医药防治提供参考。已有证据显示,中医药有助于预防新冠感染、降低密接者的转阳率、降低新冠感染患者的病毒载量;有助于改善新冠感染症状、缓解炎症、降低重症率、缩短转阴时间;有助于改善长新冠患者的消化道症状和呼吸道症状,提升肺功能。虽然中医药防治新冠感染的研究与成果发表不断增多,但其中包含大量的横断面研究、队列研究、病例报告等低等级证据类型,仍缺乏多中心、大样本、安慰剂对照、双盲设计的随机对照试验以及进一步的系统评价与Meta分析。In the past three years of the COVID-19 pandemic,traditional Chinese medicine has been involved in the prevention and treatment for the viral disease since the beginning of the outbreak,and has made remarkable achievements.This study summarized the progress and existing problems of clinical research of traditional Chinese medicine for COVID-19,and proposed strategies for future TCM studies in case of public health emergency in relation to communicable diseases,to inform practice and policy.Evidence shows that traditional Chinese medicine has potential benefits in COVID-19 prevention,treatment and recovery,may help to reduce the infection rate of close contacts,reduce the viral load;improve the symptoms,relieve inflammation,reduce the rate of progression into severe cases,and shorten the time for viral clearance;improve gastrointestinal and respiratory symptoms and lung function in patients after COVID-19.Although large number of TCM studies on COVID-19 have been published,most of the evidence is of low quality.Therefore,more multi-center,large-sample,placebo-controlled,double-blind randomized controlled trials and related systematic reviews and meta-analyses are needed in the future.

关 键 词：新型冠状病毒感染 临床研究证据 中医药 

分 类 号：R-03[医药卫生]