用于肿瘤诊疗的碳化钛基复合纳米载体系统  

Titanium Carbide-based Composite Nanocarrier System for Tumor Diagnosis and Treatment

作　　者：饶稳 李草[1] RAO Wen;LI Cao(School of Materials Science and Engineering,Hubei University,Wuhan 430062)

机构地区：[1]湖北大学料科学与工程学院,武汉430062

出　　处：《胶体与聚合物》2023年第3期131-134,139,共5页Chinese Journal of Colloid & Polymer

摘　　要：用于肿瘤治疗的多功能纳米药物受到越来越多的关注。本文开发了一种pH/近红外(NIR)双刺激响应型纳米片给药系统(DOX@Ti_(3)C_(2)-MnO_(2)-PEI)。碳化钛纳米片(Ti_(3)C_(2))在近红外辐射下具有良好的光热性能,一方面可以破坏肿瘤细胞,另一方面可以促进阿霉素(DOX)的释放。体外抗肿瘤研究结果表明,纳米药物通过化疗和光热治疗显示出显著的协同效应。DOX@Ti_(3)C_(2)-MnO_(2)-PEI复合近红外照射组细胞存活率仅为15.6%。因此,该纳米平台将是一种很有前途的肿瘤靶向药物传递系统,用于协同化疗-光热肿瘤治疗。Multifunctional nanomedicines for oncology treatment are receiving increasing attention.In this paper,a pH/near-infrared(NIR)bistimulus-responsive nanosheet drug delivery system(DOX@Ti_(3)C_(2)-MnO_(2)-PEI)was developed.Titanium carbide nanosheets(Ti_(3)C_(2))have good photothermal properties under near-infrared radiation,which can destroy tumor cells on the one hand,and promote the release of doxorubicin(DOX)on the other hand.The results of in vitro anti-tumor studies show that nanomedicines show significant synergistic effects through chemotherapy and photothermal therapy.The cell survival rate of the DOX@Ti_(3)C_(2)-MnO_(2)-PEI composite NIR irradiation group was only 15.6%.Therefore,this nanoplatform will be a promising tumor-targeted drug delivery system for synergistic chemotherapy-photothermal tumor therapy.

关 键 词：光热 药物传递系统 协同治疗 

分 类 号：R730.53[医药卫生—肿瘤]