转录因子FoxM1在恶性肿瘤中的研究进展  

Research progress of transcription factor FoxM1 in malignant tumors

作　　者：李炎宸 耿瑞璇 赵珂 陈野野[3] 郑庆飞 郑志博 LI YanChen;GENG RuiXuan;ZHAO Ke;CHEN YeYe;ZHENG QingFeit;ZHENG ZhiBo(Department of Stomatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of International Medical Services,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Thoracic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Radiation Oncology,College of Medicine and Center for Cancer Metabolism,James Comprehensive Cancer Center,The Ohio State University,Columbus Ohio 43210,USA)

机构地区：[1]中国医学科学院北京协和医学院,北京协和医院口腔科,北京100730 [2]中国医学科学院北京协和医院,国际医疗部,北京100730 [3]中国医学科学院北京协和医院,胸外科,北京100730 [4]Department of Radiation Oncology,College of Medicine and Center for Cancer Metabolism,James Comprehensive Cancer Center,The Ohio State University,Columbus Ohio 43210,USA

出　　处：《中国科学：生命科学》2023年第9期1239-1246,共8页Scientia Sinica(Vitae)

摘　　要：叉头框转录因子(Forkhead box M1,FoxM1)是转录因子的一种,被认为是多种癌症中肿瘤发展、细胞周期进展、侵袭和转移的主要调节因子,与细胞增殖等过程密切相关.近些年,随着人们对FoxM1的关注,科研人员做出了大量有价值的研究,对FoxM1的调控和功能的了解也逐步加深.许多学者以其为靶点,探索关于利用FoxM1的小分子抑制剂作为治疗癌症的新型药物.本文回顾了有关文献,系统阐述了FoxM1的基本结构、功能及在不同肿瘤中的作用,以期为诊断肿瘤性质、评估肿瘤恶性程度、选择新的治疗靶点提供参考.Forkhead box M1(FoxM1),is a transcription factor closely related to cell proliferation,the main regulator of tumor development,cell cycle,invasion and metastasis in many cancers.In recent years,much research attention has been drawn to FoxMl,and the understanding of the regulation and function of FoxM1 is gradually increasing.Researchers have explored small molecular inhibitors of FoxMl as a new type of drug for cancer treatment.This work reviews the relevant literature and systematically expounds on the basic structure and function of FoxM1 and its role in different tumors to provide a reference for diagnosing the nature of tumors,evaluating their malignancy of tumor,and selecting new therapeutic targets.

关 键 词：转录因子 FOXM1 恶性肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]