OCT4’s role and mechanism underlying oral squamous cell carcinoma  

作　　者：Yuwei DAI Ziqiong WU Yitong CHEN Xinjian YE Chaowei WANG Huiyong ZHU 

机构地区：[1]Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310003,China [2]School of Medicine,Zhejiang University,Hangzhou,310058,China [3]School of Stomatology,Zhejiang Chinese Medical University,Hangzhou,310053,China [4]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Clinical Research Center for Oral Disease of Zhejiang Province,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Hangzhou,310006,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第9期796-806,共11页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Health Commission of Zhejiang Province(No.2022RC027),China。

摘　　要：Oral squamous cell carcinoma(OSCC),a common malignancy of the head and neck,ranks sixth worldwide in terms of cancers with the most negative impact,owing to tumor relapse rates,cervical lymphnode metastasis,and the lack of an efficacious systemic therapy.Its prognosis is poor,and its mortality rate is high.Octamer-binding transcription factor 4(OCT4)is a member of the Pit-Oct-Unc(POU)family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem cells(ESCs).According to recent studies,OCT4 participates in retaining the survival of OSCC cancer stem cells(CSCs),which has far-reaching implications for the occurrence,recurrence,metastasis,and prognosis of oral carcinogenesis.Therefore,we summarize the structure,subtypes,and function of OCT4 as well as its role in the occurrence,progression,and prognosis of OSCC.

关 键 词：Cancer stem cell(CSC) Octamer-binding transcription factor 4(OCT4) Oral squamous cell carcinoma(OSCC) Prognosis Signaling pathway 

分 类 号：R739.8[医药卫生—肿瘤]