肿瘤治疗电场在头颈部癌症中的应用前景  

Application prospect of tumor treating fields technology in head and neck cancer

作　　者：李晨曦[1,2,3] 龚忠诚 赵化荣[4] 丁明超 刘慧[6] LI Chen-xi;GONG Zhong-cheng;ZHAO Hua-rong;DING Ming-chao;LIU Hui(Oncological Department of Oral and Maxillofacial Surgery,First Affiliated Hospital of Xinjiang Medical University,School&Hospital of Stomatology Xinjiang Medical University.Urumqi 830054,Xinjiang Uygur Autonomous Region;Stomatological Research Institute of Xinjiang Uygur Autonomous Region.Urumqi 830054,Xinjiang Uygur Autonomous Region;Center of Stomatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration.Wuhan 430022,Hubei Province;First Ward of Oncological Department,Cancer Center,First Affiliated Hospital of Xinjiang Medical University.Urumqi 830054,Xinjiang Uygur Autonomous Region;State Key Laboratory of Military Stomatology,National Clinical Research Center for Oral Diseases,Shaanxi Clinical Research Center for Oral Diseases,Department of Oral and Maxillofacial Traumatology&Orthognathic Surgery,Third Affiliated Hospital of Air Force Medical University.Xi'an 710032,Shaanxi Province;Department of Oral and Maxillofacial Surgery,Shanghai Stomatological Hospital&School of Stomatology,Fudan University,Shanghai Key Laboratory of Craniomaxillofacial Development and Disease,Fudan University.Shanghai 200031,China)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科,新疆乌鲁木齐830054 [2]新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐830054 [3]华中科技大学同济医学院附属协和医院口腔医学中心,口腔颌面发育与再生湖北省重点实验室,湖北武汉430022 [4]新疆医科大学第一附属医院肿瘤中心一病区(头颈),新疆乌鲁木齐830054 [5]中国人民解放军空军军医大学第三附属医院创伤与正颌外科,军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,陕西西安710032 [6]上海市口腔医院口腔颌面外科,上海市颅颌面发育与疾病重点实验室,上海200031

出　　处：《中国口腔颌面外科杂志》2023年第5期425-431,共7页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(82360481);口腔颌面发育与再生湖北省重点实验室开放课题基金(2022kqhm008);陕西省牙颌疾病临床医学研究中心开放课题(西安交通大学口腔医学院)(2020YHJB01);新疆维吾尔自治区天山创新团队课题项目(2021D14001);自治区科研创新项目(XJ2023G174);自治区自然科学基金重点项目。

摘　　要：近年来,随着免疫制剂和分子靶向药物的研发进展,针对恶性肿瘤的治疗取得了一定突破,但其仍然是目前全球疾病死亡的主要原因。肿瘤治疗电场(tumor treating fields,TTFields)是一种全新的非侵入性癌症治疗方法。TTFields可提供给肿瘤局部一个低强度(1~3 V/cm)、中频(100~300 kHz)的交变电场,通过破坏肿瘤细胞有丝分裂期的染色体分离及诱发介电泳现象,使细胞结构紊乱,发生凋亡。TTFields对正常细胞和癌细胞的敏感参数不同,对静止期细胞则没有作用,故其抗肿瘤治疗的毒副作用小、创伤小,具有很大潜力。TTFields的有效性和安全性已在多形性胶质母细胞瘤的Ⅲ期临床试验中得到验证,在其他实体瘤也相继开展了临床研究。本文就TTFields的最新研究进展进行综述,并阐述其微观机制及讨论在头颈癌中的应用前景。In recent years,major breakthroughs have been made in the treatment of malignant tumours with research and development progress of immunologic agents and molecular targeted drugs,but it is still the main cause of global disease death.Tumour treating fields(TTFields)is a new non-invasive approach to cancer treatment.TTFields can provide a kind of low-intensity(1-3 V/cm),intermediate frequency(100-300 kHz)alternating electric fields delivered locally to the tumour,which can destroy the chromosome segregation of mitotic tumour cells and induce dielectrophoresis to arise cell structure disturbance and apoptosis.The sensitive parameters of TTFields for normal and cancerous cells are different,but TTFields has no effect on quiescent cells.Hence,it has the advantages of fewer side effects and less trauma,and has great potential.Additionally,its efficacy and safety have been verified in phase III clinical trials of glioblastoma multiforme.Some clinical trials on TTFields have also been carried out in other kinds of solid tumours.This article reviewed the latest research progress of TTFields,expounding its micromechanism and discussing its application prospects in head and neck cancer.

关 键 词：医学物理学 头颈部 恶性肿瘤 肿瘤电场治疗 

分 类 号：R739.8[医药卫生—肿瘤]