大动物缺血性卒中模型  

Ischemic stroke model in large animals

作　　者：何小夺 陈健[2] 吴隆飞 丁玉川[1] 吴迪[1] He Xiaoduo;Chen Jian;Wu Longfei;Ding Yuchuan;Wu Di(Sino-American Institute of Neuroscience,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院中美神经科学研究所,北京100053 [2]首都医科大学宣武医院神经外科,北京100053

出　　处：《国际脑血管病杂志》2023年第6期467-471,共5页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82071466,81871022)。

摘　　要：由于多项转化研究的失败,卒中治疗学术产业圆桌会议建议,应使用大动物局灶性脑缺血模型进行临床前研究。特别是,目前卒中治疗进入血管再通新时代。常用于急性缺血性卒中模型的大动物包括狗、猪、羊和非人灵长类动物,可用于模拟患者脑缺血和再灌注(血管再通)的各个方面。虽然大动物因为在解剖学和生理学方面更接近人类而具有巨大优势,但也存在解剖和生理学特异性以及伦理限制等问题。文章对开颅手术和血管内介入方法制备的大动物缺血性卒中模型进行了总结,期望帮助科研人员选择最合适的大动物缺血性卒中模型,进而推动卒中转化研究的开展。Due to the failure of multiple translational researches,Stroke Therapy Academic Industry Roundtable(STAIR)recommends the use of large animal models of focal cerebral ischemia for preclinical researches.Especially,stroke treatment has currently entered a new era of vascular recanalization.Large animals commonly used in acute ischemic stroke models include dogs,swine,sheep,and non-human primates,which can be used to simulate various aspects of cerebral ischemia and reperfusion(vascular recanalization)in patients.Although large animals have significant advantages due to their proximity to humans in anatomy and physiology,there are also issues with anatomical and physiological specificity and ethical limitations.This article summarizes the large animal ischemic stroke models prepared by craniotomy and endovascular intervention,hoping to help researchers select the most appropriate large animal ischemic stroke model,and then promote the development of stroke translational research.

关 键 词：卒中 脑缺血 疾病模型 动物 狗 猪 绵羊 灵长目 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]