椎基底动脉延长扩张症的动物模型  

Animal models of vertebrobasilar dolichoectasia

作　　者：李玺 张怀亮[2,3] 张道培 Li Xi;Zhang Huailiang;Zhang Daopei(Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Encephalopathy,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450099,China;Vertigo Center,Brain Disease Hospital of the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450099,China)

机构地区：[1]河南中医药大学,郑州450000 [2]河南中医药大学第一附属医院脑病科,郑州450099 [3]河南中医药大学第一附属医院脑病医院眩晕中心,河南省眩晕病诊疗中心,河南中医药大学眩晕病研究所,郑州450099

出　　处：《国际脑血管病杂志》2023年第6期472-476,共5页International Journal of Cerebrovascular Diseases

基　　金：河南省科技研发计划联合基金(222301420080);河南省高等学校重点科研项目(22A320036)。

摘　　要：椎基底动脉延长扩张症(vertebrobasilar dolichoectasia,VBD)是一种脑血管变异性疾病。研究表明,VBD进一步发展会造成严重残疾甚至死亡。VBD的发病机制至今仍不明确,临床尚无特异性防治方案。因此,建立稳定可靠的动物模型有助于进一步了解VBD的病理生理学机制和潜在治疗靶点。文章对现有VBD动物模型的建立方法和研究进展进行了综述。Vertebrobasilar dolichoectasia(VBD)is a cerebrovascular variant disease.Researches have shown that further development of VBD may lead to severe disability and even death.The pathogenesis of VBD is still unclear,and there is no specific clinical prevention and treatment scheme.Therefore,establishing a stable and reliable animal model helps to further understand the pathophysiological mechanisms and potential therapeutic targets of VBD.This article reviews the establishment methods and research progress of the available VBD animal models.

关 键 词：椎底动脉供血不足 疾病模型 动物 椎基底动脉延长扩张症 

分 类 号：R743[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]