CCL11、MK对分化型甲状腺癌患者预后的评估价值  

Diagnostic value of CCL11 and MK in prognosis of patients with differentiated thyroid carcinoma

作　　者：张福明[1] 张祎苒 王萌 崔静[2] Zhang Fu-Ming;Zhang Yi-Ran;Wang Meng;Cui Jing(Department of Laboratory,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China;Department of Nuclear Medicine,Henan Provincial People's Hospital,Zhengzhou,Henan 450003,China)

机构地区：[1]河南省人民医院检验科,河南郑州450003 [2]河南省人民医院核医学科,河南郑州450003

出　　处：《解放军医学杂志》2023年第9期1048-1054,共7页Medical Journal of Chinese People's Liberation Army

基　　金：河南省科技研发专项(162102310015)。

摘　　要：目的探讨CC修饰趋化因子11(CCL11)、中期因子(MK)对分化型甲状腺癌(DTC)患者预后的评估价值。方法纳入2015年1月-2017年1月河南省人民医院收治的150例DTC患者作为DTC组,另选取同期150例良性甲状腺病变患者为良性组,150名健康志愿者为对照组。比较三组血清CCL11、MK水平。DTC患者按预后情况分为生存、死亡亚组,比较生存与死亡患者的临床资料,采用Cox回归分析DTC预后的影响因素;采用受试者工作特征(ROC)曲线分析血清CCL11、MK水平对DTC预后的评估价值。结果与对照组比较,DTC组、良性组确诊时血清CCL11、MK水平升高,且DTC组高于良性组(P<0.05);DTC组、良性组术后3 d血清CCL11、MK水平均低于确诊时,且DTC组高于良性组(P<0.05);DTC患者生存135例,死亡15例;DTC生存与死亡患者的年龄、肿瘤直径、TNM分期、淋巴结转移、包膜侵犯、分化程度及血清甲状腺球蛋白(Tg)、CCL11、MK水平比较,差异有统计学意义(P<0.05);Cox回归分析结果显示,TNM分期、淋巴结转移及血清Tg、CCL11、MK水平为DTC预后的影响因素(P<0.05);ROC曲线分析结果显示,血清CCL11、MK水平对DTC预后的评估价值较高,二者联合时预测效能更高(敏感度为93.33%,特异度为73.33%,ROC曲线下面积为0.835)。结论DTC患者血清CCL11、MK水平异常升高,二者联合检测对DTC预后的评估价值较高。Objective To investigate the prognostic value of C-C motif chemokine ligand 11(CCL11)and midkine(MK)in serum of patients with differentiated thyroid carcinoma(DTC).Methods One hundred and fifty patients with DTC admitted in Henan Provincial People's Hospital from January 2015 to January 2017 were selected as DTC group,150 patients with benign thyroid disease in the same period were selected as benign group,and 150 healthy volunteers were selected as control group.The serum CCL11 and MK levels of the three groups were compared.Patients in DTC group were divided into survival subgroup and death subgroup according to their prognosis.The clinical data between survival and death patients were compared.Cox regression analysis was used to analyze the factors affecting the prognosis of DTC patients.The receiver operating characteristic(ROC)curve was established to evaluate the diagnostic value of serum CCL11 and MK levels in the prognosis of DTC.Results Compared with control group,the levels of serum CCL11 and MK increased in DTC group and benign group,and the levels were higher in DTC group than in benign group(P<0.05).On the 3rd day after operation,the levels of serum CCL11 and MK were lower in both DTC group and benign group than those at the time of diagnosis,and still higher in DTC group than in benign group(P<0.05).In DTC group,135 patients survived and 15 died.The age,tumor diameter,TNM stage,lymph node metastasis,capsular invasion,differentiation degree and serum thyroglobulin(Tg),CCL11,MK levels were significantly different(P<0.05)between the survived and dead patients with DTC.Cox regression analysis showed that TNM stage,lymph node metastasis and serum Tg,CCL11,MK levels were the prognostic factors of DTC(P<0.05).The results of ROC analysis showed that serum CCL11 and MK levels were of high value in diagnosis of DTC prognosis,and the diagnostic efficiency was higher when they were combine used(sensitivity 93.33%,specificity 73.33%,AUC 0.835).Conclusions The serum levels of CCL11 and MK were abnormally elevated

关 键 词：分化型甲状腺癌 CC修饰趋化因子11 中期因子 预后 

分 类 号：R736.1[医药卫生—肿瘤]