前清蛋白对自体移植治疗B细胞非霍奇金淋巴瘤患者预后的影响分析  

Prognostic impact of prealbumin on B-cell non-Hodgkin′s lymphoma patients treated with autologous transplantation

作　　者：李庆容 罗承昕 徐双年 曾东风 万佳 LI Qingrong;LUO Chengxin;XU Shuangnian;ZENG Dongfeng;WAN Jia(Center for Hematology,the First Affiliated Hospital of the Army Medical University,Chongqing 400038,China;Department of Hematology,Army Specialty Medical Center,Chongqing 400042,China)

机构地区：[1]陆军军医大学第一附属医院血液病中心,重庆400038 [2]陆军特色医学中心血液内科,重庆400042

出　　处：《国际检验医学杂志》2023年第18期2249-2253,共5页International Journal of Laboratory Medicine

基　　金：重庆科卫联合医学科研项目(2020FYYX153)。

摘　　要：目的 探讨前清蛋白水平等因素对经自体造血干细胞移植的B细胞非霍奇金淋巴瘤患者预后的影响。方法 回顾性分析2006-2017年于陆军军医大学第一附属医院接受自体造血干细胞移植治疗的107例B细胞非霍奇金淋巴瘤患者的临床资料,通过Kaplan-Meier生存分析、Log-rank检验和Cox比例风险回归模型分析患者预后及预后影响因素。结果 107例患者移植后的中位随访时间为52.0个月,3年无进展生存率及总生存率分别为70.0%及79.5%。低前清蛋白组无进展生存率及总生存率与高前清蛋白组比较差异均有统计学意义(P=0.002、0.015)。多因素Cox回归分析提示前清蛋白低于0.15 g/L为影响无进展生存率的独立危险因素(HR=3.42,95%CI:1.47~7.95,P=0.004),前清蛋白低于0.15 g/L(HR=3.39,95%CI:1.28~8.94,P=0.014)及总蛋白水平低于60 g/L(HR=4.33,95%CI:1.68~11.14,P=0.002)为影响总生存率的独立危险因素。结论 自体造血干细胞移植前血清前清蛋白水平低与B细胞非霍奇金淋巴瘤患者预后不良相关。Objective To investigate the effect of prealbumin levels and other factors on the prognosis of patients with B-cell non-Hodgkin′s lymphoma transplanted by autologous hematopoietic stem cells.Methods The clinical data of totally 107 cases of B-cell non-Hodgkin′s lymphoma who received autologous stem cell transplantation in the the First Affiliated Hospital of the Army Medical University from January 2006 to December 2017 were retrospectively analyzed,and the prognosis and prognosis influencing factors of patients were analyzed by Kaplan-Meier survival analysis,Log-rank test,and Cox proportional risk regression model.Results The median follow-up time after transplantation in 107 patients was 52.0 months,and the three-year progression-free survival rate and overall survival rate were 70.0%and 79.5%,respectively.There were statistically significant differences in progression-free survival rate and overall survival rate between the low prealbumin group and the high prealbumin group(P=0.002,0.015).Multivariate Cox regression analysis suggested that prealbumin below 0.15 g/L was an independent risk factor for progression-free survival rate(HR=3.42,95%CI:1.47-7.95,P=0.004),prealbumin below 0.15 g/L(HR=3.39,95%CI:1.28-8.94,P=0.014)and total protein levels below 60 g/L(HR=4.33,95%CI:1.68-11.14,P=0.002)were independent risk factors affecting the overall survival rate.Conclusion Low serum prealbumin level before autologous hematopoietic stem cell transplantation is associated with poor prognosis in B-cell non-Hodgkin′s lymphoma patients.

关 键 词：自体造血干细胞移植 B细胞非霍奇金淋巴瘤 预后 前清蛋白 

分 类 号：R733.1[医药卫生—肿瘤]