针吸细胞学联合免疫细胞化学对转移性恶性黑色素瘤的诊断价值  

The value of fine needle aspiration cytology combined with immunocytochemistry in the diagnosis of metastatic malignant melanoma

作　　者：朱玉秋 朱立强 江涛 方先勇 黄荣 赵利[3] ZHU Yuqiu;ZHU Liqiang;JIANG Tao;FANG Xianyong;HUANG Rong;ZHAO Li(Laboratory Medicine Department,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221000,China;Laboratory Medicine Department,Jiawang District People’s Hospital,Xuzhou,Xuzhou,Jiangsu 221011,China;Laboratory Medicine Department,Xuzhou Cancer Hospital,Xuzhou,Jiangsu 221000,China)

机构地区：[1]徐州医科大学附属医院检验科,江苏徐州221000 [2]徐州市贾汪区人民医院检验科,江苏徐州221011 [3]徐州市肿瘤医院检验科,江苏徐州221000

出　　处：《医药前沿》2023年第23期19-22,共4页Journal of Frontiers of Medicine

摘　　要：目的:分析针吸细胞学联合免疫细胞化学对淋巴结转移性恶性黑色素瘤的诊断价值。方法:回顾性分析2020年1月—2022年12月术前在徐州医科大学附属医院细胞室和2022年1—12月曾在徐州市贾汪区人民医院细胞室做细针吸取细胞学(FNAC)检查并经组织病理学确诊的13例淋巴结转移性恶性黑色素瘤患者的细针吸取细胞学标本,对细针吸取细胞学的形态特点、免疫细胞化学结果及联合诊断准确率进行分析。结果:13例淋巴结转移性恶性黑色素瘤中,11例针吸细胞学诊断为恶性黑色素瘤(其中9例联合了免疫细胞化学染色),1例被误诊为恶性淋巴瘤,1例穿刺标本取材不满意。针吸细胞学联合免疫细胞化学对恶性黑色素瘤诊断准确率为84.6%(11/13)。结论:淋巴结转移性恶性黑色素瘤的针吸细胞形态学特征复杂多变,细胞形态学诊断对无黑色素颗粒的转移性恶性黑色素瘤诊断相对困难,制作细胞块进行免疫细胞化学染色,可获得更准确的诊断结果。Objective To evaluate the value of fine needle aspiration cytology combined with immunocytochemistry in the diagnosis of malignant melanoma with lymph node metastasis.Methods The fine needle aspiration cytology(FNAC)specimens of 13 patients with lymph node metastatic malignant melanoma confirmed by histopathology in the cell laboratory of the Affiliated Hospital of Xuzhou Medical University from January 2020 to December 2022 and in the cell Laboratory of Xuzhou Jiawang District People’s Hospital from January to December 2022 were retrospectively analyzed.The morphological characteristics of fine needle aspiration cytology,immunocytochemistry results and combined diagnostic accuracy were analyzed.Results Among the 13 cases of malignant melanoma with lymph node metastasis,11 cases were diagnosed as malignant melanoma by fine needle aspiration cytology(9 cases were combined with immunocytochemical staining),1 case was misdiagnosed as malignant lymphoma,and 1 case was not satisfied with the biopsy specimen.The diagnostic accuracy of fine needle aspiration cytology combined with immunocytochemistry for malignant melanoma was 84.6%(11/13).Conclusions The morphological characteristics of needle aspiration cells in metastatic malignant melanoma are complex and changeable.It is relatively difficult to diagnose metastatic malignant melanoma without melanin granules by cell morphology alone.More accurate diagnosis results can be obtained by making cell blocks and immunohistochemical staining.

关 键 词：转移性恶性黑色素瘤 细针吸取细胞学 免疫细胞化学染色 诊断 

分 类 号：R739.9[医药卫生—肿瘤]